J Knee Surg 2020; 33(02): 111-118
DOI: 10.1055/s-0039-3400755
Special Focus Section
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Extended Oral Antibiotics and Infection Prophylaxis after a Primary or Revision Total Knee Arthroplasty

Cierra S. Hong
1   Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina
,
Collin S. Black
1   Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina
,
Sean P. Ryan
2   Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina
,
Thorsten M. Seyler
2   Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina
› Author Affiliations

Funding None.
Further Information

Publication History

14 March 2019

21 October 2019

Publication Date:
03 December 2019 (online)

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Abstract

One of the most common reasons for failure of primary total knee arthroplasty and need for revision surgery is periprosthetic infection. Antibiotics are one of the mainstays of treatment to address prosthetic joint infections, but the route of administration and timing of delivery to optimize patient outcomes are debated. This article reviews the use and attributes of commonly used oral antibiotics, especially extended or long-term utilization, as prophylaxis and treatment for prosthetic joint infections in a primary or revision total knee arthroplasty, which include debridement, antibiotics, and implant retention, one-stage and two-stage exchange arthroplasty.