Reply to: Calcium/Citrate Ratio and Risk of Kidney Stone
Does the Urinary Calcium/Citrate Ratio Add to the Diagnostic Workup of Children at
Risk of Kidney Stones? A Cross-Sectional Study
We read the publication on “Does the Urinary Calcium/Citrate (UCa/UCi) Ratio Add to
the Diagnostic Workup of Children at Risk of Kidney Stones?” with a great interest.
Lee et al noted in the article “UCa/UCi rather than UCi/UCr may be more predictive in the clinical setting when evaluating
for nephrolithiasis.[1]” The result in this report is concordant with the previous publication by DeFoor
et al.[2] Nevertheless, there is an important consideration regarding the urine calcium and
citrate measurement. The sexual variation should also be mentioned. For urine calcium,
there is no sexual variation; however, a sexual variation is reported for urine citrate.[3] This variation should be kept in mind while interpreting the UCa/UCi ratio in pediatric
patients.
