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Synfacts 2020; 16(03): 0363
DOI: 10.1055/s-0039-1691660
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Chlorofusin Cyclic Peptide Synthesis

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Desai P, Pfeiffer SS, Boger DL. * The Scripps Research Institute, La Jolla, USA
Synthesis of the Chlorofusin Cyclic Peptide: Assignment of the Asparagine Stereochemistry.

Org. Lett. 2003;
5: 5047-5050
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Further Information

Publication History

Publication Date:
18 February 2020 (online)

 
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Key words

chlorofusin - cyclic peptides - coupling reagents - macrocycles

Significance

Cyclic peptides with unique molecular topologies have attracted attention from the fields of biochemistry and medicinal chemistry. In 2003, Boger and co-workers synthesized the cyclic peptide of chlorofusin, consisting of nine amino acid residues.


 

Comment

The nine amino acids were assembled from four subunits. Subsequent cyclization using coupling reagents proceeded smoothly to give the 27-membered macrocycle in a moderate yield.


 

 


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