Gold-Catalyzed Enantioselective Cyclizations of Enynes through Remote Enantioinduction
Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote C 2-Chiral Element.
J. Am. Chem. Soc. 2019;
17 September 2019 (online)
Various cyclizations were realized in an enantioselective fashion through the use of a modified JohnPhos ligand with a distal C 2 2,5-diarrylpyrrolidine.
Hydrocyclization products were used successfully in the first enantioselective total syntheses of three natural products from the carexane family.