Zuccarello G,
Mayans JG,
Escofet I,
Scharnagel D,
Kirillova MS,
Pérez-Jimeno AH,
Calleja P,
Boothe JR,
Echavarren AM.
* Barcelona Institute of Science and Technology and Universitat Rovira i Virgili, Tarragona, Spain
Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote
C
2-Chiral Element.
J. Am. Chem. Soc. 2019;
141: 11858-11863
Key words
gold catalysis - remote enantioinduction - enynes - carexanes
Significance
Various cyclizations were realized in an enantioselective fashion through the use of a modified JohnPhos ligand with a distal C
2 2,5-diarrylpyrrolidine.
Comment
Hydrocyclization products were used successfully in the first enantioselective total syntheses of three natural products from the carexane family.
