The Kulinkovich Reaction
Titanium(IV) Isopropoxide-Catalyzed Formation of 1-Substituted Cyclopropanols in the Reaction of Ethylmagnesium Bromide with Methyl Alkanecarboxylates.
Synthesis 1991; 234-234
17 September 2019 (online)
In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.
Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.