The Kulinkovich Reaction

Paul Knochel; Moritz Balkenhohl

doi:10.1055/s-0039-1690669

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Synfacts 2019; 15(10): 1143
DOI: 10.1055/s-0039-1690669

Metals in Synthesis

The Kulinkovich Reaction

Contributor(s):

Paul Knochel

,

Moritz Balkenhohl

Kulinkovich OG. * Sviridov SV, Vasilevski DA. Belarusian State University, Minsk, Belarus
Titanium(IV) Isopropoxide-Catalyzed Formation of 1-Substituted Cyclopropanols in the Reaction of Ethylmagnesium Bromide with Methyl Alkanecarboxylates.

Synthesis 1991; 234-234

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Further Information

Publication History

Publication Date:
17 September 2019 (online)

Abstract
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Key words

cyclopropanes - Grignard reagent - titanium

Significance

In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.

Comment

Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.

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