Synfacts 2019; 15(10): 1143
DOI: 10.1055/s-0039-1690669
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

The Kulinkovich Reaction

Paul Knochel
Moritz Balkenhohl
Kulinkovich OG. * Sviridov SV, Vasilevski DA. Belarusian State University, Minsk, Belarus
Titanium(IV) Isopropoxide-Catalyzed Formation of 1-Substituted Cyclopropanols in the Reaction of Ethylmagnesium Bromide with Methyl Alkanecarboxylates.

Synthesis 1991; 234-234
Further Information

Publication History

Publication Date:
17 September 2019 (online)



In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.



Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.