J Pediatr Intensive Care 2019; 08(03): 164-169
DOI: 10.1055/s-0039-1683991
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Continuous Renal Replacement Therapy for Treatment of Severe Attacks of Inborn Errors of Metabolism

Ayse Filiz Yetimakman
1   Division of Pediatric Intensive Care, Department of Pediatrics, Hacettepe University, Ankara, Turkey
,
Selman Kesici
2   Department of Pediatrics, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara, Turkey
,
Murat Tanyildiz
1   Division of Pediatric Intensive Care, Department of Pediatrics, Hacettepe University, Ankara, Turkey
,
Benan Bayrakci
1   Division of Pediatric Intensive Care, Department of Pediatrics, Hacettepe University, Ankara, Turkey
› Author Affiliations

Funding None.
Further Information

Publication History

08 August 2018

21 February 2019

Publication Date:
27 March 2019 (online)

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Abstract

Severe metabolic crises in children with inborn errors of metabolism can result in mortality or severe morbidities where continuous renal replacement therapy (CRRT) can be lifesaving. Clinical data, the pediatric risk of mortality (PRISM) scores calculated in the first 24 hours, and pediatric logistic organ dysfunction (PELOD) scores calculated in the last 24 hours before CRRT, were studied. Overall, CRRT was successful in restoring metabolic balance in 72% of patients. PELOD scores before CRRT were lower in survivors (p = 0.02). Despite numerous comorbid factors, CRRT can be used effectively in management of metabolic crises. Early intervention with this therapy before occurrence of complications must be targeted.

Note

The work was conducted in Hacettepe University Faculty of Medicine, Pediatric Intensive Care Unit; Dr Sami Ulus Maternity and Children's Training and Research Hospital, Pediatric Intensive Care Unit and Ankara Children's Hematology; and Oncology Training and Research Hospital, Pediatric Intensive Care Unit, Ankara, Turkey.