Abstract
Concussion is a transitory brain injury resulting from a blow to the head. Concussion
is considered a mild traumatic brain injury (mTBI), which is self-limited. Repetitive
mTBI has been associated with chronic, progressive neurological damage. Extreme biochemical
changes occur in neuron cells as a result of mTBI. These metabolic disturbances may
reflect the symptoms observed in patients who had suffered concussions. However, it
has been difficult to correlate clinical signs and symptoms. Currently, there are
no laboratory tests to diagnose concussion, though several biomarkers are being investigated.
Further studies are needed to elucidate the biochemical details of the metabolic cascade
and the associated time frame, which will help determine when an athlete can safely
return to the game.
Keywords
mild traumatic brain injury - concussion - chronic traumatic encephalopathy - second
impact syndrome