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Neuropediatrics 2019; 50(02): 103-110
DOI: 10.1055/s-0038-1677515
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

Renée Lampe
1   Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Orthopedic Department, University Hospital “rechts der Isar,” Technical University of Munich, Munich, Germany
2   Markus Würth Stiftungsprofessur for Cerebral Palsy and Paediatric Neuroorthopaedics, Orthopedic Department, Technical University of Munich, Munich, Germany
,
Varvara Turova
1   Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Orthopedic Department, University Hospital “rechts der Isar,” Technical University of Munich, Munich, Germany
,
Nikolai Botkin
3   Mathematical Faculty, Chair of Mathematical Modelling (M6), Technical University of Munich, Garching, Germany
,
Laura Eckardt
4   Pediatric Department I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
,
Ursula Felderhoff-Müser
4   Pediatric Department I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
,
Esther Rieger-Fackeldey
5   Pediatric Department, University Hospital “rechts der Isar,” Technical University of Munich, Munich, Germany
,
Ana Alves-Pinto
1   Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Orthopedic Department, University Hospital “rechts der Isar,” Technical University of Munich, Munich, Germany
,
Andrey Kovtanyuk
1   Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Orthopedic Department, University Hospital “rechts der Isar,” Technical University of Munich, Munich, Germany
,
Irina Sidorenko
3   Mathematical Faculty, Chair of Mathematical Modelling (M6), Technical University of Munich, Garching, Germany
› Author Affiliations
Further Information

Publication History

13 April 2018

09 December 2018

Publication Date:
29 January 2019 (online)

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Abstract

Intracerebral hemorrhage (ICH) is the most frequent complication in postnatal development of preterm infants. The purpose of the present work is the statistical evaluation of seven standard paraclinical parameters and their association to the development of ICH. Clinical records of 265 preterm infants with gestational age (GA) 23 to 30 weeks were analyzed. According to ICH status, patients were divided into control (without ICH) and affected (with ICH) groups. Mean values of paraclinical parameters at each week of gestation were compared. Different ICH grades, periods before and after ICH were considered separately. Lower hematocrit, SaO2, and pH were statistically significant for preterm infants with 23 to 30 weeks GA and diagnosis of ICH relative to infants without ICH. Additionally, for preterm infants with 27 to 30 weeks GA, higher C-reactive protein, as well as lower values of thrombocytes were associated with the occurrence of ICH. Preterm infants with 23 to 26 weeks GA showed C-reactive protein values similar to those in the group without ICH and lower levels of thrombocytes after bleeding. Significant differences in paraclinical parameters between preterm infants with and without ICH may constitute useful indicators for closer clinical observation of preterm infants at risk of ICH.

Keywords

risk factors - gestational age - statistical analysis - odds ratio

Financial Disclosure

The authors have no financial relationships relevant to this article to disclose.


 

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