Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia

Rakesh Rao; Shamik Trivedi; Amy Distler; Steve Liao; Zachary Vesoulis; Christopher Smyser; Amit M. Mathur

doi:10.1055/s-0038-1676973

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2019; 36(13): 1337-1343
DOI: 10.1055/s-0038-1676973

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia

Rakesh Rao

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

,

Shamik Trivedi

²Division of Newborn Medicine, Ann and Robert Laurie School of Medicine, Chicago, Illinois

,

Amy Distler

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

,

Steve Liao

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

,

Zachary Vesoulis

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

,

Christopher Smyser

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

,

Amit M. Mathur

¹Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri

› Institutsangaben

Abstract

Objective To review developmental outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH).

Study Design Neonates ≥35 weeks' gestation with mild HIE/TH (TH group, n = 30) were matched with healthy term-born infants (control group, n = 30) and reviewed for the presence and severity of magnetic resonance imaging (MRI)-detected neurological injury. Neurodevelopmental outcomes were assessed using the Bayley Scales of Infant Development (BSID).

Results MRI injury was present in 13/30 (43.3%) neonates (11 mild, 1 moderate, and 1 severe injuries) in the TH group. The mean (standard deviation [SD]) corrected age at BSID III was 29.3 (3.9) months in the controls compared with 14.7 (3.9) months in the TH group (p < 0.01). The mean (SD) cognitive, language, and motor composite scores in neonates in the TH group (n = 16, 53.3%) and control groups (n = 30, 100%) were 99.4 (17.1) versus 93.0 (12.3), (p = 0.15), 89.5 (15.5) versus 100.2 (18.4), (p = 0.054), and 93.1 (15.4) versus 100.8 (16.3) (p = 0.13), respectively.

Conclusion Developmental outcomes of neonates with mild HIE/TH were similar to healthy, term-born neonates.

Keywords

neurodevelopmental outcomes - magnetic resonance imaging - mild hypoxic-ischemic encephalopathy - therapeutic hypothermia

Volltext

Referenzen

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