Download PDF
Am J Perinatol 2019; 36(11): 1205-1210
DOI: 10.1055/s-0038-1676481
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers

Didem Arman
1   Division of Neonatology, Department of Pediatrics, Suleymaniye Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey
,
Secil Ercin
2   Division of Neonatology, Department of Pediatrics, American Hospital, Istanbul, Turkey
,
Sevilay Topcuoğlu
3   Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey
,
Ayşem Kaya
4   Section of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey
,
Taner Yavuz
5   Division of Pediatric Cardiology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
,
Güner Karatekin
3   Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey
,
Fahri Ovalı
6   Neonatal Intensive Care Unit, Department of Pediatrics, Goztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

20 July 2018

19 October 2018

Publication Date:
24 December 2018 (online)

Also available at
   Permissions and Reprints

Abstract

Objective The present study aimed to assess the global oxidant and antioxidant status in infants born to preeclamptic mothers and their correlation with cardiac functions.

Study Design We compared 40 infants born to preeclamptic mothers with 40 premature infants born to normotensive mothers. We assessed the relationship between echocardiographic measurements and total antioxidant capacity (TAC) and total oxidant status (TOS) values.

Results In the study group, TAC, TOS, and oxidative stress index (OSI) levels were significantly higher in the cord blood (p = 0.03, 0.04, and 0.039, respectively) than in the control group. We did not observe any correlation between echocardiographic measurements and TAC, TOS, and OSI levels in infants born to preeclamptic mothers.

Conclusion Compared with the control group, despite higher TAC levels in infants born to preeclamptic mothers, concurrent elevated OSI levels reveal that the oxidant–antioxidant balance is disturbed in favor of oxidants. Furthermore, the findings of this study suggest that echocardiographic parameters are unaffected by the oxidant status.

Keywords

prematurity - preeclampsia - oxidative stress - cardiac functions
 

  • References

  • 1 American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol 2013; 122 (05) 1122-1131
    CrossrefPubMedSearch in Google Scholar
  • 2 Landy HJ. The impact of maternal illness of the neonate. In: MacDonald M, Seshia M, Mullett M, eds. Avery's Neonatology. Philadelphia: Lippincott Williams and Wilkins; 2005:205–209
  • 3 Roberts JM, Lain KY. Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002; 23 (05) 359-372
    CrossrefPubMedSearch in Google Scholar
  • 4 Siti HN, Kamisah Y, Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol 2015; 71: 40-56
    CrossrefPubMedSearch in Google Scholar
  • 5 Madamanchi NR, Vendrov A, Runge MS. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol 2005; 25 (01) 29-38
    CrossrefPubMedSearch in Google Scholar
  • 6 Rinaudo P, Wang E. Fetal programming and metabolic syndrome. Annu Rev Physiol 2012; 74: 107-130
    CrossrefPubMedSearch in Google Scholar
  • 7 Wu CS, Nohr EA, Bech BH, Vestergaard M, Catov JM, Olsen J. Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study. Am J Obstet Gynecol 2011; 204 (02) 157.e1-157.e5
    CrossrefPubMedSearch in Google Scholar
  • 8 Rani V, Deep G, Singh RK, Palle K, Yadav UC. Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci 2016; 148: 183-193
    CrossrefPubMedSearch in Google Scholar
  • 9 Lazdam M, de la Horra A, Pitcher A. , et al. Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?. Hypertension 2010; 56 (01) 159-165
    CrossrefPubMedSearch in Google Scholar
  • 10 Lewandowski AJ, Augustine D, Lamata P. , et al. Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation 2013; 127 (02) 197-206
    CrossrefPubMedSearch in Google Scholar
  • 11 Davis EF, Newton L, Lewandowski AJ. , et al. Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. Clin Sci (Lond) 2012; 123 (02) 53-72
    CrossrefPubMedSearch in Google Scholar
  • 12 Redman CWG, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta 2009; 30 (Suppl A): S38-S42
    CrossrefPubMedSearch in Google Scholar
  • 13 Lazdam M, Davis EF, Lewandowski AJ. , et al. Prevention of vascular dysfunction after preeclampsia: a potential long-term outcome measure and an emerging goal for treatment. J Pregnancy 2012; 2012: 704146
    PubMedSearch in Google Scholar
  • 14 Furuya M, Kurasawa K, Nagahama K. , et al. Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia. J Pregnancy 2011; 2011: 123717
    PubMedSearch in Google Scholar
  • 15 Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard score, expanded to include extremely premature infants. J Pediatr 1991; 119 (03) 417-423
    CrossrefPubMedSearch in Google Scholar
  • 16 Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004; 37 (04) 277-285
    CrossrefPubMedSearch in Google Scholar
  • 17 Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38 (12) 1103-1111
    CrossrefPubMedSearch in Google Scholar
  • 18 Harma M, Harma M, Erel O. Measurement of the total antioxidant response in preeclampsia with a novel automated method. Eur J Obstet Gynecol Reprod Biol 2005; 118 (01) 47-51
    CrossrefPubMedSearch in Google Scholar
  • 19 Lopez L, Colan SD, Frommelt PC. , et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr 2010; 23 (05) 465-495
    CrossrefPubMedSearch in Google Scholar
  • 20 Devereux RB, Alonso DR, Lutas EM. , et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57 (06) 450-458
    CrossrefPubMedSearch in Google Scholar
  • 21 Leal CA, Schetinger MR, Leal DB. , et al. Oxidative stress and antioxidant defenses in pregnant women. Redox Rep 2011; 16 (06) 230-236
    CrossrefPubMedSearch in Google Scholar
  • 22 Zhang C, Williams MA, Sanchez SE. , et al. Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women. Am J Epidemiol 2001; 153 (06) 572-580
    CrossrefPubMedSearch in Google Scholar
  • 23 Serdar Z, Gür E, Colakoethullarý M, Develioethlu O, Sarandöl E. Lipid and protein oxidation and antioxidant function in women with mild and severe preeclampsia. Arch Gynecol Obstet 2003; 268 (01) 19-25
    CrossrefPubMedSearch in Google Scholar
  • 24 Suhail M, Suhail S, Gupta BK, Bharat V. Malondialdehyde and antioxidant enzymes in maternal and cord blood, and their correlation in normotensive and preeclamptic women. J Clin Med Res 2009; 1 (03) 150-157
    PubMedSearch in Google Scholar
  • 25 Sharma JB, Sharma A, Bahadur A, Vimala N, Satyam A, Mittal S. Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet 2006; 94 (01) 23-27
    CrossrefPubMedSearch in Google Scholar
  • 26 Tastekin A, Ors R, Demircan B, Saricam Z, Ingec M, Akcay F. Oxidative stress in infants born to preeclamptic mothers. Pediatr Int 2005; 47 (06) 658-662
    CrossrefPubMedSearch in Google Scholar
  • 27 Altunhan H, Annagür A, Kurban S, Ertuğrul S, Konak M, Örs R. Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers. J Obstet Gynaecol Res 2013; 39 (05) 898-904
    CrossrefPubMedSearch in Google Scholar
  • 28 Turunen R, Andersson S, Laivuori H. , et al. Increased postnatal inflammation in mechanically ventilated preterm infants born to mothers with early-onset preeclampsia. Neonatology 2011; 100 (03) 241-247
    CrossrefPubMedSearch in Google Scholar
  • 29 Christensen KL, Mulvany MJ. Location of resistance arteries. J Vasc Res 2001; 38 (01) 1-12
    PubMedSearch in Google Scholar
  • 30 Panza JA, Quyyumi AA, Brush Jr JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323 (01) 22-27
    CrossrefPubMedSearch in Google Scholar
  • 31 Landmesser U, Spiekermann S, Dikalov S. , et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 2002; 106 (24) 3073-3078
    CrossrefPubMedSearch in Google Scholar
  • 32 Heymes C, Bendall JK, Ratajczak P. , et al. Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol 2003; 41 (12) 2164-2171
    CrossrefPubMedSearch in Google Scholar
  • 33 Giordano FJ. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 2005; 115 (03) 500-508
    CrossrefPubMedSearch in Google Scholar
  • 34 Ijsselmuiden AJ, Musters RJ, de Ruiter G. , et al. Circulating white blood cells and platelets amplify oxidative stress in heart failure. Nat Clin Pract Cardiovasc Med 2008; 5 (12) 811-820
    CrossrefPubMedSearch in Google Scholar
  • 35 Liu T, Takimoto E, Dimaano VL. , et al. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circ Res 2014; 115 (01) 44-54
    CrossrefPubMedSearch in Google Scholar
  • 36 Ago T, Liu T, Zhai P. , et al. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 2008; 133 (06) 978-993
    CrossrefPubMedSearch in Google Scholar
  • 37 Burgoyne JR, Mongue-Din H, Eaton P, Shah AM. Redox signaling in cardiac physiology and pathology. Circ Res 2012; 111 (08) 1091-1106
    CrossrefPubMedSearch in Google Scholar
  • 38 Erickson JR, Joiner ML, Guan X. , et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell 2008; 133 (03) 462-474
    CrossrefPubMedSearch in Google Scholar
  • 39 James AT, Corcoran JD, Hayes B, Franklin O, El-Khuffash A. The effect of antenatal magnesium sulfate on left ventricular afterload and myocardial function measured using deformation and rotational mechanics imaging. J Perinatol 2015; 35 (11) 913-918
    CrossrefPubMedSearch in Google Scholar