The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers

Didem Arman; Secil Ercin; Sevilay Topcuoğlu; Ayşem Kaya; Taner Yavuz; Güner Karatekin; Fahri Ovalı

doi:10.1055/s-0038-1676481

American Journal of Perinatology, Table of Contents

Am J Perinatol 2019; 36(11): 1205-1210
DOI: 10.1055/s-0038-1676481

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers

Didem Arman

¹Division of Neonatology, Department of Pediatrics, Suleymaniye Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey

,

Secil Ercin

²Division of Neonatology, Department of Pediatrics, American Hospital, Istanbul, Turkey

,

Sevilay Topcuoğlu

³Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey

,

Ayşem Kaya

⁴Section of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey

,

Taner Yavuz

⁵Division of Pediatric Cardiology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

,

Güner Karatekin

³Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey

,

Fahri Ovalı

⁶Neonatal Intensive Care Unit, Department of Pediatrics, Goztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey

› Author Affiliations

Abstract

Objective The present study aimed to assess the global oxidant and antioxidant status in infants born to preeclamptic mothers and their correlation with cardiac functions.

Study Design We compared 40 infants born to preeclamptic mothers with 40 premature infants born to normotensive mothers. We assessed the relationship between echocardiographic measurements and total antioxidant capacity (TAC) and total oxidant status (TOS) values.

Results In the study group, TAC, TOS, and oxidative stress index (OSI) levels were significantly higher in the cord blood (p = 0.03, 0.04, and 0.039, respectively) than in the control group. We did not observe any correlation between echocardiographic measurements and TAC, TOS, and OSI levels in infants born to preeclamptic mothers.

Conclusion Compared with the control group, despite higher TAC levels in infants born to preeclamptic mothers, concurrent elevated OSI levels reveal that the oxidant–antioxidant balance is disturbed in favor of oxidants. Furthermore, the findings of this study suggest that echocardiographic parameters are unaffected by the oxidant status.

Keywords

prematurity - preeclampsia - oxidative stress - cardiac functions

Full Text

References

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