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Digestive Disease Interventions 2019; 03(01): 038-045
DOI: 10.1055/s-0038-1676065
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Image-Guided Ablation of Neuroendocrine Tumor Liver Metastases

J. Louis Hinshaw
1   Department of Radiology, The University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
,
Kelli Moore
1   Department of Radiology, The University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
,
Monika Rastogi
1   Department of Radiology, The University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
› Author Affiliations
Further Information

Publication History

14 September 2019

09 October 2018

Publication Date:
01 February 2019 (online)

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Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that require a multidisciplinary process to determine the most appropriate approach for patient management and therapy. Over time, the treatment algorithms have continuously evolved as the options have improved and changed. This manuscript reviews the current and potential role of image-guided ablation in the treatment of patients with metastatic NET to the liver. While some attention will be devoted to the basics of ablation, the focus will be on the role of image-guided ablation in these patients and issues specific to the treatment of NET's liver metastases with ablation.

Keywords

ablation - neuroendocrine tumor - symptoms
 

  • References

  • 1 Cavalcoli F, Rausa E, Conte D, Nicolini AF, Massironi S. Is there still a role for the hepatic locoregional treatment of metastatic neuroendocrine tumors in the era of systemic targeted therapies?. World J Gastroenterol 2017; 23 (15) 2640-2650
    CrossrefPubMedGoogle Scholar
  • 2 Surveillance, Epidemiology, and End Results (SEER) Program. Research Data (1973–2015), National Cancer Institute, DCCPS, Surveillance Research Program 2018. www.seer.cancer.gov . Accessed January 5, 2018
    PubMed
  • 3 Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97 (04) 934-959
    CrossrefPubMedGoogle Scholar
  • 4 Yao JC, Hassan M, Phan A. , et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26 (18) 3063-3072
    CrossrefPubMedGoogle Scholar
  • 5 Ito T, Lee L, Jensen RT. Treatment of symptomatic neuroendocrine tumor syndromes: recent advances and controversies. Expert Opin Pharmacother 2016; 17 (16) 2191-2205
    CrossrefPubMedGoogle Scholar
  • 6 Jensen RTNJ, Oberg K. Neuroendocrine tumors. In: Feldman MFL, Brandt LJ. , eds. Sleisenger and Fordtran's Gastrointestinal Liver Diseases. Vol 1. Philadelphia, PA: Elsevier Saunders; 2015: 501-541
    Google Scholar
  • 7 Norlén O, Stålberg P, Zedenius J, Hellman P. Outcome after resection and radiofrequency ablation of liver metastases from small intestinal neuroendocrine tumours. Br J Surg 2013; 100 (11) 1505-1514
    CrossrefPubMedGoogle Scholar
  • 8 Saxena A, Chua TC, Sarkar A. , et al. Progression and survival results after radical hepatic metastasectomy of indolent advanced neuroendocrine neoplasms (NENs) supports an aggressive surgical approach. Surgery 2011; 149 (02) 209-220
    CrossrefPubMedGoogle Scholar
  • 9 Frilling A, Akerström G, Falconi M. , et al. Neuroendocrine tumor disease: an evolving landscape. Endocr Relat Cancer 2012; 19 (05) R163-R185
    CrossrefPubMedGoogle Scholar
  • 10 Tomassetti P, Campana D, Piscitelli L. , et al. Endocrine tumors of the ileum: factors correlated with survival. Neuroendocrinology 2006; 83 (5-6): 380-386
    CrossrefPubMedGoogle Scholar
  • 11 Hinshaw JL, Lubner MG, Ziemlewicz TJ, Lee Jr FT, Brace CL. Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation--what should you use and why?. Radiographics 2014; 34 (05) 1344-1362
    CrossrefPubMedGoogle Scholar
  • 12 Potretzke TA, Ziemlewicz TJ, Hinshaw JL. , et al. Microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: a comparison of efficacy at a single center. J Vasc Interv Radiol 2016; 27 (05) 631-638
    CrossrefPubMedGoogle Scholar
  • 13 Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW, Lee Jr FT. Microwave ablation with multiple simultaneously powered small-gauge triaxial antennas: results from an in vivo swine liver model. Radiology 2007; 244 (01) 151-156
    CrossrefPubMedGoogle Scholar
  • 14 Lubner MG, Brace CL, Ziemlewicz TJ, Hinshaw JL, Lee Jr FT. Microwave ablation of hepatic malignancy. Semin Intervent Radiol 2013; 30 (01) 56-66
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Wright AS, Lee Jr FT, Mahvi DM. Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol 2003; 10 (03) 275-283
    CrossrefPubMedGoogle Scholar
  • 16 Steinmüller T, Kianmanesh R, Falconi M. , et al; Frascati Consensus Conference participants Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 2008; 87 (01) 47-62
    CrossrefPubMedGoogle Scholar
  • 17 Dodd III GD, Dodd NA, Lanctot AC, Glueck DA. Effect of variation of portal venous blood flow on radiofrequency and microwave ablations in a blood-perfused bovine liver model. Radiology 2013; 267 (01) 129-136
    CrossrefPubMedGoogle Scholar
  • 18 Grandhi MS, Lafaro KJ, Pawlik TM. Role of locoregional and systemic approaches for the treatment of patients with metastatic neuroendocrine tumors. J Gastrointest Surg 2015; 19 (12) 2273-2282
    CrossrefPubMedGoogle Scholar
  • 19 Bertot LC, Sato M, Tateishi R, Yoshida H, Koike K. Mortality and complication rates of percutaneous ablative techniques for the treatment of liver tumors: a systematic review. Eur Radiol 2011; 21 (12) 2584-2596
    CrossrefPubMedGoogle Scholar
  • 20 Correa-Gallego C, Fong Y, Gonen M. , et al. A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases. Ann Surg Oncol 2014; 21 (13) 4278-4283
    CrossrefPubMedGoogle Scholar
  • 21 Ding J, Jing X, Liu J. , et al. Complications of thermal ablation of hepatic tumours: comparison of radiofrequency and microwave ablative techniques. Clin Radiol 2013; 68 (06) 608-615
    CrossrefPubMedGoogle Scholar
  • 22 Liu Y, Li S, Wan X. , et al. Efficacy and safety of thermal ablation in patients with liver metastases. Eur J Gastroenterol Hepatol 2013; 25 (04) 442-446
    CrossrefPubMedGoogle Scholar
  • 23 Meloni MF, Chiang J, Laeseke PF. , et al. Microwave ablation in primary and secondary liver tumours: technical and clinical approaches. Int J Hyperthermia 2017; 33 (01) 15-24
    CrossrefPubMedGoogle Scholar
  • 24 Liang P, Wang Y, Yu X, Dong B. Malignant liver tumors: treatment with percutaneous microwave ablation--complications among cohort of 1136 patients. Radiology 2009; 251 (03) 933-940
    CrossrefPubMedGoogle Scholar
  • 25 Livraghi T, Meloni F, Solbiati L, Zanus G. ; Collaborative Italian Group using AMICA system Complications of microwave ablation for liver tumors: results of a multicenter study. Cardiovasc Intervent Radiol 2012; 35 (04) 868-874
    CrossrefPubMedGoogle Scholar
  • 26 Felker ER, Lee-Felker SA, Ajwichai K. , et al. Intraductal cooling via a nasobiliary tube during radiofrequency ablation of central liver tumors reduces biliary injuries. AJR Am J Roentgenol 2015; 204 (06) 1329-1335
    CrossrefPubMedGoogle Scholar
  • 27 de Baere T, Deschamps F, Tselikas L. , et al. GEP-NETS update: interventional radiology: role in the treatment of liver metastases from GEP-NETs. Eur J Endocrinol 2015; 172 (04) R151-R166
    CrossrefPubMedGoogle Scholar
  • 28 Maithel SK, Fong Y. Hepatic ablation for neuroendocrine tumor metastases. J Surg Oncol 2009; 100 (08) 635-638
    CrossrefPubMedGoogle Scholar
  • 29 Akyildiz HY, Mitchell J, Milas M, Siperstein A, Berber E. Laparoscopic radiofrequency thermal ablation of neuroendocrine hepatic metastases: long-term follow-up. Surgery 2010; 148 (06) 1288-1293 , discussion 1293
    CrossrefPubMedGoogle Scholar
  • 30 Jones NB, Shah MH, Bloomston M. Liver-directed therapies in patients with advanced neuroendocrine tumors. J Natl Compr Canc Netw 2012; 10 (06) 765-774
    CrossrefPubMedGoogle Scholar
  • 31 Taner T, Atwell TD, Zhang L. , et al. Adjunctive radiofrequency ablation of metastatic neuroendocrine cancer to the liver complements surgical resection. HPB (Oxford) 2013; 15 (03) 190-195
    CrossrefPubMedGoogle Scholar
  • 32 Liang P, Dong B, Yu X. , et al. Prognostic factors for percutaneous microwave coagulation therapy of hepatic metastases. AJR Am J Roentgenol 2003; 181 (05) 1319-1325
    CrossrefPubMedGoogle Scholar
  • 33 Takahashi H, Kahramangil B, Berber E. Local recurrence after microwave thermosphere ablation of malignant liver tumors: results of a surgical series. Surgery 2018; 163 (04) 709-713
    CrossrefPubMedGoogle Scholar
  • 34 Mazzaglia PJ, Berber E, Milas M, Siperstein AE. Laparoscopic radiofrequency ablation of neuroendocrine liver metastases: a 10-year experience evaluating predictors of survival. Surgery 2007; 142 (01) 10-19
    CrossrefPubMedGoogle Scholar
  • 35 Mohan H, Nicholson P, Winter DC. , et al. Radiofrequency ablation for neuroendocrine liver metastases: a systematic review. J Vasc Interv Radiol 2015; 26 (07) 935-942.e1
    CrossrefPubMedGoogle Scholar
  • 36 Bissonnette RT, Gibney RG, Berry BR, Buckley AR. Fatal carcinoid crisis after percutaneous fine-needle biopsy of hepatic metastasis: case report and literature review. Radiology 1990; 174 (3 Pt 1): 751-752
    CrossrefPubMedGoogle Scholar
  • 37 Majeed F, Porter TR, Tarantolo S, Duhachek-Stapelman A, Xie F, Elhendy A. Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome. Eur J Echocardiogr 2007; 8 (05) 386-389
    CrossrefPubMedGoogle Scholar
  • 38 Raut CP, Kulke MH, Glickman JN, Swanson RS, Ashley SW. Carcinoid tumors. Curr Probl Surg 2006; 43 (06) 383-450
    CrossrefPubMedGoogle Scholar
  • 39 Sinha V, Dyer P, Shuvro RC, Geh JI, Karandikar S. Case of carcinoid crisis following a fine-needle biopsy of hepatic metastasis. Eur J Gastroenterol Hepatol 2009; 21 (01) 101-103
    CrossrefPubMedGoogle Scholar
  • 40 Woltering EA, Wright AE, Stevens MA. , et al. Development of effective prophylaxis against intraoperative carcinoid crisis. J Clin Anesth 2016; 32: 189-193
    CrossrefPubMedGoogle Scholar
  • 41 Gillams A, Cassoni A, Conway G, Lees W. Radiofrequency ablation of neuroendocrine liver metastases: the Middlesex experience. Abdom Imaging 2005; 30 (04) 435-441
    CrossrefPubMedGoogle Scholar
  • 42 Massimino K, Harrskog O, Pommier S, Pommier R. Octreotide LAR and bolus octreotide are insufficient for preventing intraoperative complications in carcinoid patients. J Surg Oncol 2013; 107 (08) 842-846
    CrossrefPubMedGoogle Scholar
  • 43 Akahane M, Koga H, Kato N. , et al. Complications of percutaneous radiofrequency ablation for hepato-cellular carcinoma: imaging spectrum and management. Radiographics 2005; 25 (Suppl (Suppl. 01) S57-S68
    CrossrefPubMedGoogle Scholar
  • 44 Rhim H, Yoon KH, Lee JM. , et al. Major complications after radio-frequency thermal ablation of hepatic tumors: spectrum of imaging findings. Radiographics 2003; 23 (01) 123-134 , discussion 134–136
    CrossrefPubMedGoogle Scholar
  • 45 Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee Jr FT. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 2005; 236 (01) 132-139
    CrossrefPubMedGoogle Scholar
  • 46 Welch BT, Schmitz JJ, Atwell TD. , et al. Evaluation of infectious complications following percutaneous liver ablation in patients with bilioenteric anastomoses. Abdom Radiol (NY) 2017; 42 (05) 1579-1582
    CrossrefPubMedGoogle Scholar
  • 47 Howenstein MJ, Sato KT. Complications of radiofrequency ablation of hepatic, pulmonary, and renal neoplasms. Semin Intervent Radiol 2010; 27 (03) 285-295
    Article in Thieme ConnectPubMedGoogle Scholar
  • 48 Kim KR, Thomas S. Complications of image-guided thermal ablation of liver and kidney neoplasms. Semin Intervent Radiol 2014; 31 (02) 138-148
    Article in Thieme ConnectPubMedGoogle Scholar
  • 49 Meloni MF, Andreano A, Bovo G. , et al. Acute portal venous injury after microwave ablation in an in vivo porcine model: a rare possible complication. J Vasc Interv Radiol 2011; 22 (07) 947-951
    CrossrefPubMedGoogle Scholar
  • 50 Ziemlewicz TJ, Hinshaw JL, Lubner MG. , et al. Percutaneous microwave ablation of hepatocellular carcinoma with a gas-cooled system: initial clinical results with 107 tumors. J Vasc Interv Radiol 2015; 26 (01) 62-68
    CrossrefPubMedGoogle Scholar
  • 51 Chiang J, Willey BJ, Del Rio AM, Hinshaw JL, Lee FT, Brace CL. Predictors of thrombosis in hepatic vasculature during microwave tumor ablation of an in vivo porcine model. J Vasc Interv Radiol 2014; 25 (12) 1965-1971.e2
    CrossrefPubMedGoogle Scholar
  • 52 Chiang J, Cristescu M, Lee MH. , et al. Effects of microwave ablation on arterial and venous vasculature after treatment of hepatocellular carcinoma. Radiology 2016; 281 (02) 617-624
    CrossrefPubMedGoogle Scholar
  • 53 Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF, Goldberg SN. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 2003; 226 (02) 441-451
    CrossrefPubMedGoogle Scholar
  • 54 Andreano A, Galimberti S, Franza E. , et al. Percutaneous microwave ablation of hepatic tumors: prospective evaluation of postablation syndrome and postprocedural pain. J Vasc Interv Radiol 2014; 25 (01) 97-105.e1, 2
    CrossrefPubMedGoogle Scholar
  • 55 Dodd III GD, Napier D, Schoolfield JD, Hubbard L. . Percutaneous radiofrequency ablation of hepatic tumors: postablation syndrome. AJR Am J Roentgenol 2005; 2005 (185) 51-57
    PubMedGoogle Scholar
  • 56 Wah TM, Arellano RS, Gervais DA. , et al. Image-guided percutaneous radiofrequency ablation and incidence of post-radiofrequency ablation syndrome: prospective survey. Radiology 2005; 237 (03) 1097-1102
    CrossrefPubMedGoogle Scholar