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J Knee Surg 2019; 32(10): 995-1000
DOI: 10.1055/s-0038-1675217
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Retrospective Comparative Study of Different Methods of Blood Management in Total Knee Replacement

Eleni Pappa
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
,
Nikolaos Vergados
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
,
Emanouil Spiridakis
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
,
George Chountas
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
,
Anna Apostolopoulou
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
,
Savas Sourmelis
1   1st Department of Orthopaedics, ‘Hygeia’ General Hospital of Athens, Marousi, Greece
› Author Affiliations
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Publication History

18 December 2017

07 September 2018

Publication Date:
13 November 2018 (online)

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Abstract

Perioperative blood management is essential to minimize allogeneic blood transfusion in total knee replacement. The effect of preoperative administration of erythropoietin, intraoperative cell saver, tranexamic acid, and restrictive transfusion strategies on allogeneic transfusion is studied in total knee replacement. A retrospective comparative study of 106 patients who underwent total knee replacement in different time periods was performed. Group A (n 1 = 45) underwent restrictive strategies of transfusion between 2009 and 2010. Group B (n 2 = 24) includes patients where erythropoietin of either 10.000 IU or 20.000 IU was given preoperatively. Patients of Group C (n 3 = 21) underwent autologous washed erythrocytes transfusion through a cell saver. Lastly, in Group D (n 4 = 15) tranexamic acid dose of 1 gr IV was given intraoperatively. The preoperative and discharge hemoglobin together with total units of blood transfusion and creatinine levels was studied. Tranexamic acid noted the least units of blood transfusion (mean = 0.82 units/patient, p < 0.001, CI 95%) in contrast to the two regimens of erythropoietin (1.16 units/patient) OrthoPAT (1.43 units/patient) and restrictive strategies (1.92 units/patient). The mean preoperative hemoglobin was 13.37 g/dL with no statistical difference among the groups of patients. The postoperative mean hemoglobin was 10.59 with no statistical difference among the groups of patients too. Additionally, the mean creatinine level was 0.93 mg/dL; however, no statistical difference among the groups of patients was noted. Finally, tranexamic acid seemed to be the most cost-effective regime. In our study, tranexamic acid proved its superiority concerning the postoperative blood transfusion on patients undergoing total knee replacement, in comparison with the other existing methods of perioperative blood management. This is a Level III, retrospective comparative study.

Keywords

blood management - total knee replacement - tranexamic acid
 

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