Circulating Fibrinogen Degradation Products (FDP) in Dog Blood after Intravenous Thrombin Infusion

E Kowalski; A. Z Budzyński; Maria Kopeć; Z. S Latallo; B Lipiński; Z Węgrzynowicz

doi:10.1055/s-0038-1656283

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1965; 13(01): 012-024
DOI: 10.1055/s-0038-1656283

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Circulating Fibrinogen Degradation Products (FDP) in Dog Blood after Intravenous Thrombin Infusion

E Kowalski

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

,

A. Z Budzyński

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

,

Maria Kopeć

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

,

Z. S Latallo

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

,

B Lipiński

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

,

Z Węgrzynowicz

¹Department of Radiobiology and Health Protection, Institute of Nuclear Research Warsaw 9

› Author Affiliations

Abstract

Summary

1. The effect of thrombin infusion into dogs was studied with the use of ¹³¹I-labelled fibrinogen and compared with the better known effect of plasmin.

2. Rapid infusion of thrombin brings about almost complete defibrination followed by the appearance of high molecular fragments of the fibrinogen molecule.

3. Some anticoagulant activity of plasma, but not as pronounced as after plasmin infusion, is observed in the case of thrombin infusion.

4. A hypothesis is discussed, according to which the proteolytic degradation of fibrin which is formed as a result of thrombin action, and cleared out of the circulating blood, does occur. The products are then released back into the circulation system.

Full Text

References

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