Abnormal Plasma Clots in Hemophilia

Richard E. Bettigole; James W. Hampton; Robert M. Bird

doi:10.1055/s-0038-1655617

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1964; 12(01): 331-337
DOI: 10.1055/s-0038-1655617

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Abnormal Plasma Clots in Hemophilia

Authors

Richard E. Bettigole^*

¹Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma
James W. Hampton

¹Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma
Robert M. Bird

¹Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma

Abstract

Summary and Conclusions

A technique is described for the examination of thin plasma clots with the electron microscope, by which the clots of nine patients with classical hemophilia and five normal controls were studied. The hemophiliacs’ plasma clots were strikingly different from normal, with relatively straight, wide fibrin strands. This difference appeared to be due to their long clotting times. It is proposed that this abnormal end-product of fibrin polymerization in hemophilia, perhaps together with the decreased platelet clumping which also was observed, may be a cause of the functional inadequacy of blood clots in hemophilia.

Presented in part in abstract, Clinical Research 11: 190, 1963 and clinical Research 11: 293, 1963.

Full Text

References

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