Thromb Haemost 1967; 18(03/04): 332-341
DOI: 10.1055/s-0038-1655040
Originalarbeiten — Original Articles — Travaux Originaux
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Factors Influencing the Consumption of Factor X (Stuart-Prower Factor) during Intrinsic Coagulation

J Niemetz M. D.
1   Department of Hematology of the Mount Sinai Hospital and the School of Medicine, New York, N. Y. 10029
› Author Affiliations

Supported in part by TJSPHS Grant # HE 08631, the National Hemophilia Foundation and the Albert A. List, Frederick Machlin and Anna Ruth Lowenburg Funds.Presented in part at the Meeting of the Federation of American Societies for Experimental Biology 1966 (Fed. Proc. 25, # 2, 256, 1966).
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Publication Date:
26 June 2018 (online)

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Summary

1. Factor X is consumed during in vitro intrinsic coagulation of normal blood when both surface activation and either bovine AHG or phospholipid such as cephalin, hemolysate, PS, PE, or mixture of PS and PE are present. Neither surface activation, AHG or phospholipid alone produces significant consumption of factor X.

2. Consumption of factor X did not occur in hemophilic bloods (AHG or PTC deficient) when both surface activation and phospholipid were present.

3. The consumption of factor X in blood from human subjects, with high factor VIII levels, when surface activation was provided, was only moderately augmented compared with results in blood with a normal factor VIII level.

4. The consumption of factor X in the blood of a patient with a SLE inhibitor was similar to that in normal blood when both contact activation and phospholipids were supplied.