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Thromb Haemost 1963; 09(01): 175-188
DOI: 10.1055/s-0038-1654972
Originalarbeiten — Original Articles — Travaux Originaux
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The Streptokinase Reactivity Test. I. Standardization

A Amery
1   University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)
,
H Maes
1   University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)
,
J Vermylen
1   University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)
,
M Verstraete
1   University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)
› Author Affiliations
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Publication History

Publication Date:
21 June 2018 (online)

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Summary

1. An attempt was made to standardize a method which determines the reactivity of a given blood sample with streptokinase (SKRT).

2. The nature of the thrombin and streptokinase used can greatly influence the test.

3. The 20 minutes value is less influenced by a number of parameters than other points on the streptokinase versus lysis time plot.

 

  • References

  • 1 Tillett W. S, Garner R. L. The fibrinolytic activity of hemolytic streptococci. J. exp. Med. 58: 485 1933;
    CrossrefPubMedGoogle Scholar
  • 2 Johnson A. J, Fletcher A. P, McCarty W. R, Tillett W. S. The intravascular use of streptokinase. Ann. N. Y. Acad. Sci. 68: 201 1957;
    CrossrefPubMedGoogle Scholar
  • 3 Fletcher A. Personal communication.
    PubMedGoogle Scholar
  • 4 Deutsch E, Fischer M. Die Wirkung intravenös applizierter Streptokinase auf Fibrinolyse und Blutgerinnung. Thrombos. Diathes. haemorrh. 04: 482 1960;
    PubMedGoogle Scholar
  • 5 Fischbacher W. Beitrag zur fibrinolytischen Therapie mit Streptokinase und Fibrinolysin. Thrombos. Diathes. haemorrh. 06: 547 1961;
    PubMedGoogle Scholar
  • 6 Nilsson I. H, Olow B. Fibrinolysis induced by streptokinase in man. Acta chir. scand. 123: 247 1962;
    PubMedGoogle Scholar
  • 7 Johnson A. J, McCarty W. R. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J. clin. Invest. 38: 1627 1959;
    CrossrefPubMedGoogle Scholar
  • 8 Amery A, Vermylen J, Maes H, Verstraete M. Enhancing the fibrinolytic activity in human blood by occlusions of blood vessels. Thrombos. Diathes. haemorrh. 07: 70 1962;
    PubMedGoogle Scholar
  • 9 Fearnley G. R, Rivill R, Tweed J. M. Observation on the inactivation of fibrinolytic activity in shed blood. Clin. Sci. 02: 309 1952;
    PubMedGoogle Scholar
  • 10 Devreker R, Vermylen C, Verstraete M. The purification of thrombin for use as a fibrinolytically inert reagent. Proc. Xth Coll. Protides of the Biological Fluids, Bruges 1962
    PubMedGoogle Scholar
  • 11 Fearnley G. R, Tweed JMoore. Evidence of an active fibrinolytic enzyme in the plasma of normal people with observations on inhibition associated with the presence of calcium. Clin. Sci. 12: 81 1953;
    PubMedGoogle Scholar