Download PDF
Thromb Haemost 1965; 14(01/02): 184-201
DOI: 10.1055/s-0038-1654863
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

An Experimental Obliterating Thromboangiitis Limited to the Posterior Part of the Body*

H Selye
1   Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada
,
K Nielsen
1   Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada
,
Beatriz Tuchweber
1   Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada
› Author AffiliationsThis work was supported by the U. S. Army, Medical Research and Development Command (Contract No. DA-49- 193-MD-2039), the Medical Research Council of Canada and the U. S.P.H.S., National Heart Institute (Grant No. HE-06182-04).
Further Information

Publication History

Publication Date:
24 July 2018 (online)

    Permissions and Reprints

Summary

After a brief outline of the principles involved in the production of thrombo- hemorrhagic phenomena (THP) with special organotropic localizations, an experimental technique is described which permits the production of acrocyanosis and thrombohemorrhagic lesions largely limited to the posterior part of the body.

This phenomenon can be consistently produced by certain combinations of THP elicitors, anaphylactoid agents and noradrenaline (NA). The most effective combination among those tested is thorium dextrin (Th-Din) plus tannic acid plus NA.

Several drugs can decisively influence the course of this reaction. Most notable among these are Neo-Antergan (an antihistaminic) which sensitizes for the production of the aboral THP, while heparin (presumably through its anticoagulant effect) and Dibenamine (presumably through its antiadrenergic action) offer virtually complete protection.

When only Th-Din plus tannic acid is given, there develops an intense but reversible cyanosis in the hind paws and tail; additional treatment with NA induces obliterating thromboangiitis with hemorrhages and gangrene. None of these changes are produced by Th-Din, tannic acid or NA alone. Evidently, here, we are dealing with pluricausal experimental diseases whose possible relationship to Raynaud’s disease, thromboangiitis obliterans and anaphylactoid purpura is briefly discussed.

The authors wish to thank the following companies for suppling compounds used in this study: Burroughs Wellcome (Compound 48/80, Polymyxin-B sulfate); Merck, Sharp and Dohme (Periactin); Smith Kline & French (Dibenamine) ; Astra (Astrafer, Jectofer); Abbott (Dextran, Histamine phosphate); Sandoz (KB-95); Poulenc (Neo-Antergan); Benger (Aluminium Dextran).


 

  • Literature

  • 1 Selye H, Gabbiani G, Tuchweber B. The role of mastocytes in the regional fixation of blood- borne particles. Brit. J. exp. Path. 44: 38 1963;
    PubMedGoogle Scholar
  • 2 Selye H, Grasso S. Chemical production of myocardial necrosis with vascular occlusion. Brit. J. exp. Path. 42: 564 1961;
    PubMedGoogle Scholar
  • 3 Selye H, Tuchweber B. Ein durch verschiedene Agenzien erzeugbares thrombohämor- rhagisches Phänomen. Allergie und Asthma. 10: 335 1964;
    PubMedGoogle Scholar
  • 4 Selye H, Tuchweber B, Mathur R. B. Influence of Norepinephrine upon the Thrombo- hemorrhagic Action of Various Agar Preparations. Med. exp. (Basel) 13: 49 1965;
    PubMedGoogle Scholar
  • 5 Selye H, Tuchweber B, Gabbiani G. Effect of heparin upon various forms of the thrombohemorrhagic phenomenon (THP). Blood. (In press.)
    PubMedGoogle Scholar
  • 6 Selye H, Tuchweber B. Experimental production of an anaphylactoid purpura. Proc. Soc. exp. Biol. (N. Y) 118: 680 1965;
    CrossrefPubMedGoogle Scholar
  • 7 Selye H. Calciphylaxis. The University of Chicago Press; Chicago: 1962
    Google Scholar
  • 8 Selye H. The Pluricausal Cardiopathies. Charles C Thomas; Springfield, Ill: 1961
    Google Scholar
  • 9 Briot M. Molécules à longue chaîne douées de propriétés histaminolibératrices. Thèse: Université de Paris; 1958
    Google Scholar
  • 10 Clark W. G, MacKay E. M. Effect of Epinephrine, Antihistaminics and Adrenergic Blockade on Egg White Edema in Adrenal Insufficient Rats. Proc. Soc. exp. Biol. (N. Y) 72: 510 1949;
    CrossrefPubMedGoogle Scholar
  • 11 Clark W. G, MacKay E. M. Effect of 1-Epinephrine and 1-Arterenol on Egg White Edema in the Rat. Proc. Soc. exp. Biol. (N. Y) 71: 86 1949;
    CrossrefPubMedGoogle Scholar
  • 12 Swingle W. W, Fedor E. J, Maxwell R, Ben M, Barlow G. Cortisone fore-treatment of adrenalectomized rats infused with globin and dextran. Amer. J. Physiol. 172: 527 1953;
    PubMedGoogle Scholar
  • 13 Halpern B. N, Briot M. Etude pathogénique et thérapeutique du syndrome oedémateux provoqué chez le rat par l’ovalbumine. Arch. int. pharmacodyn. 82: 247 1950;
    PubMedGoogle Scholar
  • 14 Briot M, Halpern B. N. Action inhibitrice de la prométhazione (phénergan) et de l’adrénaline sur l’oedème du rat par le dextran. C. R. Soc. Biol. (Paris) 146: 21 1952;
    PubMedGoogle Scholar
  • 15 Meir R, Gross F, Desaulles P. Über die Bedeutung der Nebennieren und der Nebennieren - rindensteroide für den Ablauf entzündlicher Reaktionen. Klin. Wschr. 29: 653 1951;
    CrossrefPubMedGoogle Scholar
  • 16 Cohn J. Unusual reactions to slow epinephrine. J. Allergy. 10: 459 1939;
    CrossrefPubMedGoogle Scholar
  • 17 Herxheimer H. Urticaria following adrenaline but not noradrenaline. Lancet I: 615 1951;
    PubMedGoogle Scholar
  • 18 Marcus H. Studie über die symmetrische Gangrän. II. Experimentelle Untersuchungen über die Bedingungen der Entstehung der Gangrän. Acta med. scand. 54: 413 1921;
    PubMedGoogle Scholar
  • 19 Schmidt-Weyland P. Experimentelle Untersuchungen zur Erzeugung von Gangrän und ihre Beziehungen zur Thromboangiitis obliterans. Klin. Wschr. 11: 2148 1932;
    CrossrefPubMedGoogle Scholar
  • 20 Thomas L, Zweifach B. W. Hyperreactivity to adrenalin as a possible mechanism in endotoxin shock. 48th Ann. Meet. Am. Soc. Clin. Investigation 57 1956;
    PubMedGoogle Scholar
  • 21 Urbach E, Gottlieb P. M. Allergy (Second Edition). Grune & Stratton; New York: 1946
    Google Scholar