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Thromb Haemost 1965; 14(01/02): 176-183
DOI: 10.1055/s-0038-1654862
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Studies on Autoprothrombin C Thrombin Relationship*

R. H Landaburu
1   Institute of Pharmacology National University of Cordoba, Cordoba – Argentina
,
O Abdala
1   Institute of Pharmacology National University of Cordoba, Cordoba – Argentina
,
Susana Fulginiti
1   Institute of Pharmacology National University of Cordoba, Cordoba – Argentina
,
J Curtino
1   Institute of Pharmacology National University of Cordoba, Cordoba – Argentina
› Author AffiliationsThis investigation wwas supported by a research grant HE 06-439 from the National Institute of Health, U. S. Public Health Service and The Rockefeller Foundation.
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

In every prothrombin activation two different enzymatic reactions can be distinguished. The first reaction is the prothrombin disappearance and the second one is the thrombin formation. Autoprothrombin C catalyzes both reactions and thrombin only the first one. The inhibition of thrombin with heparin allows a more complete activation of the thrombin. The two reactions can be independently catalyzed by different substances. Heparin by itself can provide the environment for activation.

 

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