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Thromb Haemost 1965; 14(01/02): 176-183
DOI: 10.1055/s-0038-1654862
DOI: 10.1055/s-0038-1654862
Originalarbeiten — Original Articles — Travaux Originaux
Studies on Autoprothrombin C Thrombin Relationship*
This investigation wwas supported by a research grant HE 06-439 from the National Institute of Health, U. S. Public Health Service and The Rockefeller Foundation.
Further Information
Publication History
Publication Date:
24 July 2018 (online)
Summary
In every prothrombin activation two different enzymatic reactions can be distinguished. The first reaction is the prothrombin disappearance and the second one is the thrombin formation. Autoprothrombin C catalyzes both reactions and thrombin only the first one. The inhibition of thrombin with heparin allows a more complete activation of the thrombin. The two reactions can be independently catalyzed by different substances. Heparin by itself can provide the environment for activation.
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References
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