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Thromb Haemost 1965; 14(01/02): 001-011
DOI: 10.1055/s-0038-1654849
DOI: 10.1055/s-0038-1654849
Originalarbeiten — Original Articles — Travaux Originaux
Activated Human Hageman Factor (XII)*
Supported in part by USPHS grants AM-02612 and HE-08025.
Further Information
Publication History
Publication Date:
24 July 2018 (online)
Summary
An improved method for the isolation of highly purified active human Hageman factor has been described. An overall recovery of 25% with a purification of 106 has been achieved. Certain of the physical and chemical characteristics of XII have been elucidated. Selective chemical modification of functional groups and a variety of enzymatic assays have been employed in an effort to shed light on the mechanism of action of this procoagulant.
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