Summary
1. A new method where the patients own plasma is clotted by the addition of his own
whole blood hemolyzate is described. The hemolyzate here is the thromboplastinic source.
The clotting time is recorded and called the Self Thromboplastin-Prothrombin time.
This test gives abnormal results in cases with defective intrinsic prothrombin activation.
The fact that it is abnormal in hypoproconvertinemia proves that it also reflects
deficiencies in extrinsic activation of prothrombin.
2. This test is applicable for screening of hemorrhagic diseases concerning the second,
third and fourth stages of coagulation. It can be used in the control of anticoagulant
therapy with dicoumarol derivatives and heparin by means of a dilution curve.
