Thromb Haemost 1963; 10(02): 267-277
DOI: 10.1055/s-0038-1654782
Originalarbeiten — Original Article — Travaux Originaux
Schattauer GmbH

The Biological Disappearance Rate of Prothrombin, Factors VII, IX and X from Plasma in Hypothyroidism, Hyperthyroidism, and During Fever

E. A Loeliger
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
B van der Esch
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
Mieke J Mattern
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
H. C Hemker
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Summary

The biological disappearance rate of coagulation factors II, VIT, IX and X from plasma is decreased in myxoedema and increased in thyreotoxicosis. In patients with elevated body temperatures, an increase of up to three times the normal rate was observed. The clinical implications of these findings are briefly discussed.

 
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