Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1971; 25(01): 142-146
DOI: 10.1055/s-0038-1654288
DOI: 10.1055/s-0038-1654288
Originalarbeiten – Original Articles – Travaux Originaux
The Effect of Intravascular and Extravascular Coagulation on Serum Fibrin Degradation Products in Rats
This work supported in part by the Department of Medicine, Education Fund, Chicago Wesley Memorial Hospital and a grant from Blood Research, Incorporated.
Further Information
Publication History
Publication Date:
28 June 2018 (online)
Summary
Serum fibrin degradation products (FDP) were elevated following intravascular clotting in rats. The levels of these products were similar whether the blood clot remained localized in the inferior vena cava or embolized to the lung. The level of FDP increased with increasing amounts of blood clot formed. The intravascular injection of 100 u of thrombin induced high levels of FDP and resulted in death of the animals. Extravascular deposition of fibrin, either subcutaneously, intramuscularly or intraperitoneally had no effect on serum FDP.
-
References
- 1 Barnhart M. I, Cress D. C, Vettraino A. Cell fates of fibrin and products of fibrinolysis. Fed. Proc 26: 538 1967;
- 2 Benz J. J. Clotting factors and fibrinogen split products in the extravascular space. Thromb. Diath. haemorrh. (Stuttg) 19: 226 1968;
- 3 Das P. C, Allan A. G. E, Woodfield D. G, Cash J. D. Fibrin degradation products in sera of normal subjects. Brit. med. J 04: 718 1967;
- 4 Ferreira H. C, Murat L. G. An immunological method for demonstrating fibrin degradation products in serum and its use in the diagnosis of fibrinolytic states. Brit. J. Haemat 09: 299 1963;
- 5 Kwaan H. C. Tissue fibrinolytic activity studied by a histochemical method. Fed. Proc 25: 52 1966;
- 6 Linton A. L, Gavras H, Gleadle R. I, Hutchison H. E, Lawson D. H, Lever A. F, Macadam R. F, McNichol G. P, Robertson J. I. S. Microangiopathic hemolytic anemia and the pathogenesis of malignant hypertension. Lancet I: 1277 1969;
- 7 Merskey C, Kleiner G. J, Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood 28: 1 1966;
- 8 Mertens B. F, McDuffie F. C, Bowie E. J. W, Owens C. A. Rapid sensitive method for measuring fibrinogen split-products in human serum. Mayo Clin. Proc 44: 114 1969;
- 9 Nossel H. L, Niemetz J, Waxman S. A, Spector S. L. Defibrination syndrome in a patient with chronic thrombocytopenic purpura. Amer. J. Med 46: 591 1969;
- 10 Stiehm E. R, Trygstad C. W. Split products of fibrin in human renal disease. Amer. J. Med 46: 774 1969;
- 11 Wilson J. E, Winga E. R, Frenkel E. P, Pierce A. K, Johnson Jr R. L. Evidence of spontaneous fibrinolysis in thrombophlebitis and pulmonary embolism. Amer. Rev. Resp. Dis 99: 974 1969;