Réactions Plaquettaires et Processus Immunitaires

Résumé

Nous avons étudié de quelle façon les substrats et inhiteurs de la chymotrypsine inhibent l’agrégation plaquettaire induite par le collagène. Nous avons trouvé que ces substances inhibent la libération d’ADP plaquettaire provoquée par le collagène.

Cette observation, ajoutée à plusieurs autres, indique que les processus plaquettaires et mastocytaires de libération de substances intracellulaires ont plusieurs caractéristiques biologiques communes.

Le rôle possible d’une estérase plaquettaire chymotrypsinoide dans les réactions de la thrombogénèse est discuté.

Recherche Subventionnée par le Conseil de la Recherche Médicale du Canada (MA-2342) et par la Fondation du Québec des Maladies du Coeur.

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