Inhibition of Fibrinolysis in Post-Traumatic Death^[*]

Summary

The fibrinolytic system was studied in a number of autopsy cases. It was found that in contrast to most of the other autopsy cases those persons who had died later than 1 day after trauma, especially cases of fat embolism, often showed inhibition of fibrinolysis combined with the presence of intravascular fibrin in the pulmonary vessels. The importance of this observation for the pathogenesis and diagnosis of the fat embolism syndrome is discussed.

^* This investigation was supported by grants from the Swedish Medical Resear ch Council (No. B 67-12X-2035-02), The Fylgia Insurance Company's 80th Jubilee Fund (grants 1967, 1968), and ABKabi.

• References

• 1 Albrechtsen O. K. The fibrinolysis agents in saline extracts of human tissues. Scand. J. clin. Lab. Invest 10: 91 1958;
• 2 Andersson L, Nilsson I. M, Niléhn J-E, Hedner U, Granstrand B, Melander B. Experimental and clinical studies on AMCA, the antifibrinolytically active isomer of p-aminomethyl cyclohexane carbocylic acid. Scand. J. Hemat 02: 230 1965;
• 3 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem 40: 346 1952;
• 4 Busch G. Personal communication.
• 5 Blombäck B, Blombäck M. Purification of human and bovine fibrinogen. Archiv för Kemi 10: 415 1956;
• 6 Kleine D. L. Purification and crystallization of plasminogen (profibrinolysin). J. biol. Chem 204: 949 1953;
• 7 Paraskevas M, Nilsson I. M, Martinsson G. A method for determining serum inhibitors of plasminogen activation. Scand. J. clin. Lab. Invest 14: 138 1962;
• 8 Saldeen T. Om fibrinförekomsten i lungorna. Nordisk Rettsmedicinsk forenings forhand-lingar. Universitetsforlaget; Oslo: 1964: 211.
• 9 Saldeen T. The occurrence of fibrin in the lungs in an autopsy material. Virchows Arch, path. Anat 343: 20 1967;
• 10 Saldeen T. The Disappearance of Fibrin from the Pulmonary Vessels in Experimental Fat Embolism. Thrombos. Diathes. haemorrh. (Stuttg) 22: 360 1969;