Virus Infection and Blood Coagulation^[*]

Summary

By means of a new model, the fowl plague of chickens, further evidence is given that viruses may trigger blood coagulation. Macroscopically, hemorrhages were observed, whereas microscopic studies revealed platelet and fibrin thrombi in the small vessels of various organs. Hematologic studies demonstrated an increase in the clotting time and a decrease in the activities of clotting factors I, II, VIII and X, and drop in platelet counts. Heparin could diminish the hemorrhages but did not influence the survival time of the animals.

^* Supported by Grant Mu 279/1 from the Deutsche Forschungsgemeinschaft, Bad Godesberg, Germany.

¹⁾ Medical Thesis by Christina Gagel.

²⁾ Reprint request to : Prof. Lasch, Medizinische Klinik, 63 Gieβen, Germany.

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