Thromb Haemost 1967; 17(01/02): 273-276
DOI: 10.1055/s-0038-1654102
Originalarbeiten - Original Articles - Travaux Originaux
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Mechanisms of Interaction between a Phosphoinositide Anticoagulant and a Phospholipid Activator in the Stypven Type Conversion of Prothrombin to Thrombin

M. J. P Kahn
1   University of Brussels
,
R. H Bourgain
1   University of Brussels
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Supported by a grant from the “Fonds de la recherche scientifique médicale” (grant n° 542)
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Publication Date:
26 June 2018 (online)

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Summary and Conclusion

In the Stypven activation of prothrombin to thrombin, successive steps were investigated in order to locate more precisely the action of a phosphoinositide anticoagulant. The anticoagulant effect has been located precisety at the time of interaction of activated factors X and V, calcium ions and phospholipid material. When this interaction is completed, the phosphoinositide is no longer capable of demonstrating anticoagulant activity.