Diffusion Characteristics of Human Plasminogen(as Shown by Two Agar Diffusion Techniques)

Summary

The relative diffusion rates of human plasminogen in agar has been compared with immune rabbit γ globulin and with streptokinase. A ratio of 1.1106 was found for plasminogen/immune rabbit γ globulin diffusion and a ratio of 0.80 for plasminogen/ streptokinase. These values were unaltered when plasminogen in normal fresh plasma and serum was replaced by three differently prepared plasminogen concentrates. Taking the D₂₀ value for rabbit γ globulin as 4.23 × 10^–7 cm² sec⁻¹ and for streptokinase the value of 6.1 × 10^–7 cm² sec^–1, the corresponding values for human plasminogen were 4.7 and 4.9 × 10^–7 cm² sec^–1. The widely divergent D₂₀ values for human plasminogen and plasmin in the literature are reviewed and discussed.

• References

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