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Thromb Haemost 1974; 31(02): 319-327
DOI: 10.1055/s-0038-1649166
Original Article
Schattauer GmbH

A Comparative Study of Human and Monkey (Macaca irus) Fibrinogen Degradation Products

Thomas R Poskitt
1   United States Army Medical Research Laboratory Fort Knox, Kentucky
,
H Philip Fortwengler Jr.
1   United States Army Medical Research Laboratory Fort Knox, Kentucky
,
Gerald J Roth
1   United States Army Medical Research Laboratory Fort Knox, Kentucky
,
James A Eaton Jr.
1   United States Army Medical Research Laboratory Fort Knox, Kentucky
› Author Affiliations
Further Information

Publication History

Received 20 August 1973

Accepted 15 January 1974

Publication Date:
29 June 2018 (online)

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Summary

Immunochemical, physical, and anticoagulant properties of human and monkey (Macaca irus) fibrinogen degradation products (FDP’s) were compared by Immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDP’s derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans.

 

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