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Thromb Haemost 1974; 31(01): 179-186
DOI: 10.1055/s-0038-1649156
Original Article
Schattauer GmbH

Studies on the Shape Change in Rabbit Platelets Induced by Adenosine Diphosphate or Several Metabolic Inhibitors

Norio Kobayashi
1   3rd Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
,
Tadashi Maekawa
1   3rd Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
› Author Affiliations
Further Information

Publication History

Received 24 September 1973

Accepted 20 October 1973

Publication Date:
29 June 2018 (online)

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Summary

1. The shape change of platelet was induced in vitro by an addition of ADP, NEM, KCN or distilled water. The change induced by ADP occurred very rapidly.

2. Among these reagents, only ADP induced the platelet aggregation.

3. When ADP was added before the completion of the shape change by NEM, the shape change by ADP took place, while both ADP and NEM were added simultaneously, the pattern of the shape change was similar to that of ADP alone.

4. The shape change of platelet by ADP was inhibited by the previous addition of adenosine, which did not affect the shape change induced by NEM.

5. Correlation of the shape change of platelets to their aggregation was discussed.

 

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