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Thromb Haemost 1976; 36(03): 542-550
DOI: 10.1055/s-0038-1648075
DOI: 10.1055/s-0038-1648075
Original Article
Plasma Factor XIII and Platelet Factor XIII in Hyperlipaemia
Further Information
Publication History
Received
08 March 1976
Accepted
09 August 1976
Publication Date:
03 July 2018 (online)
Summary
Plasma factor XIII activity measured by a quantitative assay was found to be significantly higher in hypertriglyceridaemic patients (type IV and combined hyperlipoproteinaemia), as compared to normolipaemic controls. No such elevation in plasma factor XIII activity was found in patients with type IIa hyperlipaemia. Plasma pseudocholinesterase was found to parallel the elevated factor XIII activity in hypertriglyceridaemic subjects.
In contrast, platelet factor XIII activity was not raised in hyperlipaemic subjects, and plasma factor XIII was found to be normal in a normolipaemic subject with throm-bocythaemia.
It was concluded that there is no significant contribution from platelets to plasma factor XIII activity, and that the observed increase in plasma factor XII in hypertriglyceridaemia results from enhanced hepatic synthesis of the enzyme.
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