The Effect of Exocrine Pancreas Stimulation on the Coagulation and Fibrinolytic System in Dogs^[*]

Summary

The coagulation and fibrinolytic systems have been investigated in the dogs treated intravenously with secretin, pancreozymin and CCK.

There was significant shortening of plastic and glass clotting times, a fall in blood platelet numbers, prolongation of the prothrombin time, and a transitory inhibition of plasma euglobulin fibrinolytic activity. The greatest changes were found after CCK.

It should be stressed that the peak changes were earlier and more intense when morphine was given with the hormones.

In the authors’ opinion the present findings support the supposition concerning the role of enzymatic toxemia in hemostatic disturbances seen in acute pancreatitis.

^* Supported by Polish Academy of Science, Dept. VI.

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