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Thromb Haemost 1973; 29(01): 063-075
DOI: 10.1055/s-0038-1647746
DOI: 10.1055/s-0038-1647746
Original Article
Factors Regulating Plasma Protein Synthesis
II. Influence of Fibrinogenolytlc Products on Plasma Fibrinogen ConcentrationFurther Information
Publication History
Received
28 April 1972
Publication Date:
30 June 2018 (online)
Summary
The intravenous injection of a large amount of homologous fibrinogen in the rabbit produces typical changes in the level of circulating fibrinogen. The first peak is due to the administered fibrinogen while the second, occurring after 16 hr, is interpreted as being due to the stimulation of hepatic synthesis and release of preformed fibrinogen. This typical profile was obtained with different fibrinogen preparations but not with heterologous fibrinogen. Neither was it obtained after administration of homologous γ-globulin, α-globulin or albumin. Assuming that enhancement of hepatic synthesis might be due to fibrinogenolytic products, the effect of the injection of fibrinogen digest products (FDP) was investigated. Administration of homologous FDP causes, within 24 hours, a significant increase of the plasma fibrinogen level. The critical requirement of injecting either the protein solution or saline intravenously rather than subcutaneously is emphasized. In conclusion, FDP appear to be endowed with the novel property of stimulating fibrinogen synthesis and possibly of causing the release of preformed fibrinogen.
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References
- 1 Atencio A. C, Chao P-Y, Chen A. Y, Reeve E. B. 1969; Fibrinogen response to corticotropin preparations in rabbits. American Journal of Physiology 216: 773.
- 2 Atencio A. C, Joiner K, Reeve E. B. 1969; Experimental and control systems studies of plasma fibrinogen regulation in rabbits. American Journal of Physiology 216: 764.
- 3 Atencio A. C, Loeand L. 1970; Effect of ACTH on biosynthesis of fibrinogen in the rabbit. American Journal of Physiology 219: 1161.
- 4 Baenhaet M. I, Cress D. C, Noonan S. M, Walsh R. T. 1970. Influence of fibrinolytic products on hepatic release and synthesis of fibrinogen. In: Owren P. A, Brinkhotjs K. M, Wright I. S, Roberts H. R, Hinnom S, Kiesselbach T. H. Fibrinogen: Structural, Metabolic and Pathophysiologic Aspects. F. K. Schattauer Verlag: Stuttgart; 143.
- 5 Bocci V. 1970; Metabolism of plasma proteins. Archivio di Fisiologia 67: 314.
- 6 Bocci V, Pacini A. 1971; Factors regulating the synthesis of plasma fibrinogen. Proceedings of the International Union of Physiological Sciences. XXV International Congress, Munich July 25-31, 1971, vol. 9: 70.
- 7 Bocci V, Viti A. 1971; Factors regulating plasma protein synthesis. I. Circadian fluctuations of plasma fibrinogen mass in the rat. American Journal of Physiology 221: 719.
- 8 Chandler A. M, Snider G. A. 1970; Plasma protein biosynthesis following laparotomy and partial hepatectomy. Proceedings of the Society for Experimental Biology and Medicine 135: 415.
- 9 Chattopadhyay D. P, Cliffton E. E. 1965; Activation of rabbit plasminogen by streptokinase. American Journal of Physiology 208: 190.
- 10 Dudek G. A, Kloczewiak M, Budzynski A. Z, Latallo Z. S, Kopec M. 1970; Characterisation and comparison of macromolecular and products of fibrinogen and fibrin proteolysis by plasmin. Biochimica et Biophysica Acta 214: 44.
- 11 Fisher R. A, Yates F. 1953. Statistical tables for biological, agricultural and medical research. . Oliver and Body; London.:
- 12 Fletcher A. P, Alkjaersig N, Sherry S. 1962; Pathogenesis of the coagulation defect developing during pathological plasma proteolytic (“fibrinolytic”) states. I. The significance of fibrinogen proteolysis and circulating fibrinogen breakdown products. Journal of Clinical Investigation 41: 896.
- 13 Freeman T. 1965; Gamma globulin metabolism in normal humans and in patients. Scandinavian Journal of Haematology Suppl. 4, 76.
- 14 Gans H, Lowman J. T. 1967; The uptake of fibrin and fibrin-degradation products by the isolated perfused rat liver. Blood 29: 526.
- 15 Gornall A. G, Bardawill C. J, David M. M. 1949; Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry 177: 751.
- 16 Hilgard P, Hiemeyer V. 1970; Increased plasma fibrinogen and the release of a fibrinogen enhancing factor in tumour-bearing rats. Experientia 26: 182.
- 17 Hombtjrger F. 1945; A plasma fibrinogen-increasing factor obtained from sterile abscesses in dogs. Journal of Clinical Investigation 24: 43.
- 18 Jamieson G. A, Gaffney Jr P. J.. 1968; Nature of the high molecular weight fraction of fibrinolytic digests of human fibrinogen. Biochimica et Biophysica Acta 154: 96.
- 19 Jeejeebhoy K. N, Bruce-Robertson A, Sodtke U, Foley M. 1970; The effect of growth hormone on fibrinogen synthesis. Biochemical Journal 119: 243.
- 20 John D. W, Miller L. L. 1969; Regulation of net biosynthesis of serum albumin and acute phase plasma proteins. Journal of Biological Chemistry 244: 6134.
- 21 Koj A. 1970. Synthesis and turnover of acute-phase reactants. In: Porter R, Knight J. (eds.) Energy Metabolism in Trauma. Ciba Foundation Symposium. Churchill; London: 79.
- 22 Koj A. 1970; Acute-phase reactants and lysosomal enzymes in the blood of rats with experimental inflammation or radiation injury. Folia Biologica 18: 275.
- 23 Kowalski E. 1968; Fibrinogen derivatives and their biologic activities. Seminars in Hematology 05: 45.
- 24 Kukeal J. C, Zeineh R, Dobryszycka W, Pollitt J, Stone N. 1969; Metabolism of plasma proteins in injury states. Clinical Science 36: 221.
- 25 Lerner R. G, Rapaport S. I, Siemsen J. K, Spitzer J. M. 1968; Disappearance of fibrinogen-131I after endotoxin: effects of a first and second injection. American Journal of Physiology 214: 532.
- 26 Marder V. J, Shtjlman N. R, Carroll W. R. 1969; High molecular weight derivatives of human fibrinogen produced by plasmin. I. Physicochemical and immunological characterization. Journal of Biological Chemistry 244: 2111.
- 27 McFarlane A. S. 1963; In vivo behavior of I131fibrinogen. Journal of Clinical Investigation 42: 346.
- 28 McFarlane A. S, Todd D, Cromwell S. 1964; Fibrinogen catabolism in humans. Clinical Sciences 26: 415.
- 29 Merskey C. 1969; The quantitation of fibrinogen or fibrin split products. Thrombosis et Diathesis Haemorrhagica Suppl. 36, 195.
- 30 Merskey C, Lalezari P, Johnson A. J. 1969; A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proceedings of the Society for Experimental Biology and Medicine 131: 871.
- 31 Miller L. L, Hanavan H. R, Titthasiri N, Chowdhury A. 1964; Dominant role of the liver in the biosynthesis of the plasma proteins with special reference to the plasma muco-proteins (seromucoid) ceruloplasmin and fibrinogen. Chemistry 44: 17.
- 32 Monkhouse F. C, Milojevic S. 1960; Changes in fibrinogen level after infusion of thrombin and thromboplastin. American Journal of Physiology 199: 1165.
- 33 Pacini A, Bocci V. 1970; An evaluation of methods for determining the concentration of fibrinogen in rabbit plasma. Italian Journal of Biochemistry 19: 241.
- 34 Pessina G. P, Bocci V. 1971; Effect of hypoxia on plasma fibrinogen concentration in rabbits. Archivio di Fisiologia 68: 172.
- 35 Pessina G. P, Conti T, Pacini A, Bocci V. 1972 Factors regulating plasma protein synthesis. III. Large scale separation of rabbit fibrinogenolytic products Italian Journal of Biochemistry. in the press..
- 36 Pilgeram L. O, Pickart L. R. 1968; Control of fibrinogen biosynthesis: the role of free fatty acid. Journal Atherosclerosis Research 08: 155.
- 37 Regoeczi E. L, Henley G. E, Holloway R. C, McFarlane A. S. 1963; Turnover of 131I-labelled fibrinogen in fever. British Journal of Experimental Pathology 44: 397.
- 38 Regoeczi E. 1970; Fibrinogen catabolism: kinetics of catabolism following sudden elevation of the pool with exogenous fibrinogen. Clinical Science 38: 111.
- 39 Regoeczi E. 1971; Iodine-Labelled Fibrinogen: A review. British Journal of Haematology 20: 649.
- 40 Sherman L. A, Fletcher A. P, Sherry S. 1969; In vivo transformation between fibrinogen of varying ethanol solubilities: A pathway of fibrinogen catabolism. Journal of Laboratory and Clinical Medicine 73: 574.
- 41 Siegel N. J, Kolmen S. N. 1969; Fibrinogen: reversible sequestration associated with acidosis in situ. American Journal of Physiology 216: 707.
- 42 Snedecor G. W, Cochran W. G. 1968. Statistical methods. . The Iowa State University Press Ames; Iowa, USA.:
- 43 Thuot C, Larrieu M. J. 1971; Fibrinogen degradation products: a critical study of two assay methods. Revue Europeenne d’Etudes Cliniques et Biologiques 16: 27.
- 44 Triantaphyllopoulos D. C. 1960; Effect of intravenous injections of the anticoagulant fraction of incubated fibrinogen on blood coagulation. Canadian Journal of Biochemistry and Physiology 38: 909.
- 45 Walsh R. T, Baenhaet M. I. 1969. Clearance of coagulation and fibrinolysis products by the reticuloendothelial system. In: Mammen E. F, Anderson G. F, Baenhakt M. I. (eds.). Disseminated Intravascular Coagulation. . F. K. Schattauer Verlag; Stuttgart: 83.
- 46 Wycofe H. D. 1970; Production of fibrinogen following an endotoxin injection. Proceedings of the Society for Experimental Biology and Medicine 133: 940.
- 47 Young M. C, Kolmen S. N. 1968; Sustained lymphatic delivery of fibrinogen after induced afibrinogenemia. Thrombosis et Diathesis Haemorrhagica 19: 198.
- 48 Young M. C, Kolmen S. N. 1970; Recovery of fibrinogen in fibrinolytic dogs. Thrombosis et Diathesis Haemorrhagica 23: 50.