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Methods Inf Med 1997; 36(04/05): 364-367
DOI: 10.1055/s-0038-1636847
Original Article
Schattauer GmbH

Alveolar Oxygen Uptake and Blood Flow Dynamics in Knee Extension Ergometry

R. L. Hughson
1   Department of Kinesiology, University of Waterloo, Waterloo, Canada
,
M. J. MacDonald
1   Department of Kinesiology, University of Waterloo, Waterloo, Canada
,
J. K. Shoemaker
1   Department of Kinesiology, University of Waterloo, Waterloo, Canada
,
C. Borkhoff
1   Department of Kinesiology, University of Waterloo, Waterloo, Canada
› Author AffiliationsSupported by Natural Sciences and Engineering Research Council of Canada. MJMcD and JKS were NSERC Graduate Scholars.
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Publication History

Publication Date:
19 February 2018 (online)

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Abstract:

The relationship was studied between the increase in oxygen uptake (VO2) measured breath-by-breath at the mouth, and the increase in femoral artery blood flow measured continuously with pulsed and echo Doppler methods. Five men exercised at 50 W on a knee extension ergometer in both the supine and the upright posture. The kinetics of the responses were determined by curve fitting to obtain the mean response time (MRT = 63% of the time required to achieve steady state). In the upright position, the increase in blood flow (MRT = 12.4 ± 9.4 s, mean ± SD) was faster than the increase in VO2 (29.6 ± 9.3 s). Likewise in the supine position, blood flow increased more rapidly (25.1 + 9.7 s vs. 36.7 ± 9.6 s). It should be noted that the increase in blood flow appeared to be faster than VO2, yet when blood flow adapted more slowly in the supine posture, it had an impact on the adaptation of VO2. This suggests that blood flow might have important effects on metabolism at the onset of submaximal exercise.

Keywords:

Oxygen Uptake - Exercise - Breath-by-Breath Gas Exchange - Pulsed Doppler - Echo Doppler
 

  • REFERENCES

  • 1 Hughson RL. Exploring cardiorespiratory control mechanisms through gas exchange dynamics. Med Sei Sports Exerc 1990; 22: 72-9.
    PubMedGoogle Scholar
  • 2 Yoshida T, Whipp BJ. Dynamic asymmetries of cardiac output transients in response to muscular exercise in man. J Physiol (Lond) 1994; 480: 355-9.
    CrossrefPubMedGoogle Scholar
  • 3 Barstow TJ, Buchthal S, Zanconato S, Cooper DM. Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J Appl Physiol 1994; 77: 1742-9.
    CrossrefPubMedGoogle Scholar
  • 4 Hughson RL, Cochrane JE, Butler GC. Faster O2 uptake kinetics at onset of supine exercise with than without lower body negative pressure. J Appl Physiol 1993; 75: 1962-7.
    CrossrefPubMedGoogle Scholar
  • 5 Shoemaker JK, Naylor HL, Pozeg ZI, Hughson RL. Failure of prostaglandins to modulate the time course of blood flow during dynamic forearm exercise in humans. J Appl Physiol 1996; 81: 1516-21.
    CrossrefPubMedGoogle Scholar
  • 6 Tschakovsky ME, Shoemaker JK, Hughson RL. Vasodilation and muscle pump contribution to immediate exercise hyperemia. Am J Physiol Heart Circ Physiol 1996; 271: H1697-H1701.
    CrossrefPubMedGoogle Scholar
  • 7 Shoemaker JK, Pozeg ZI, Hughson RL. Forearm blood flow by Doppler ultrasound during rest and exercise: tests of day-to-dayrepeatability. Med Sei Sports Exerc 1996; 28: 1144-9.
    PubMedGoogle Scholar
  • 8 Hughson RL, Shoemaker JK, Tschakovsky M, Kowalchuk JM. Dependence of muscle VO2 on blood flow dynamics at the onset of forearm exercise. J Appl Physiol 1996; 81: 1619-26.
    CrossrefPubMedGoogle Scholar
  • 9 Shoemaker JK, Hodge L, Hughson RL. Cardiorespiratory kinetics and femoral artery blood velocity during dynamic knee extension exercise. J Appl Physiol 1994; 77: 2625-32.
    CrossrefPubMedGoogle Scholar
  • 10 Shoemaker JK, Phillips SM, Green HJ, Hughson RL. Faster femoral artery blood velocity kinetics at the onset of exercise following short-term training. Cardiovasc Res 1996; 31: 278-86.
    CrossrefPubMedGoogle Scholar
  • 11 Kagaya A, Ogita F. Blood flow during muscle contraction and relaxation in rhythmic exercise at different intensities. Ann Physiol Anthrop 1992; 11: 251-6.
    PubMedGoogle Scholar
  • 12 Sorensen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robertson J, Thomas O. et al. Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J 1995; 74: 247-53.
    CrossrefPubMedGoogle Scholar
  • 13 Sheriff DD, Rowell LB, Scher AM. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump. Am J Physiol Heart Circ Physiol 1993; 265: H1227-34.
    CrossrefPubMedGoogle Scholar
  • 14 Corcondilas A, Koroxenidis GT, Shepherd JT. Effect of a brief contraction of forearm muscles on forearm blood flow. J Appl Physiol 1964; 19: 142-6.
    CrossrefPubMedGoogle Scholar
  • 15 Tschakovsky ME, Shoemaker JK, Hughson RL. Beat-by-beat forearm blood flow with Doppler ultrasound and strain-gauge plethysmography. J Appl Physiol 1995; 79: 713-9.
    CrossrefPubMedGoogle Scholar
  • 16 Segal SS. Cell-to-cell communication coordinates blood flow control. Hypertension 1994; 23: 1113-20.
    CrossrefPubMedGoogle Scholar
  • 17 Gayeski TEJ, Connett RJ, Honig CR. Minimum intracellular PO2 for maximum cytochrome turnover in red muscle in situ. Am J Physiol 1987; 252: H906-15.
    PubMedGoogle Scholar
  • 18 Connett RJ, Honig CR, Gayeski TEJ, Brooks GA. Defining hypoxia: A systems view of VO2, glycolysis, energetics, and intracellular PO2 . J Appl Physiol 1990; 68: 833-42.
    CrossrefPubMedGoogle Scholar
  • 19 Wilson DF. Factors affecting the rate and energetics of mitochondrial oxidative phosphorylation. Med Sei Sports Exerc 1994; 26: 37-43.
    PubMedGoogle Scholar
  • 20 Arthur PG, Hogan MC, Bebout DE, Wagner PD, Hochachka PW. Modeling the effects of hypoxia on ATP turnover in exercising muscle. J Appl Physiol 1992; 73: 737-42.
    CrossrefPubMedGoogle Scholar
  • 21 Hogan MC, Nioka S, Brechue WF, Chance B. A 31P-NMR study of tissue respiration in working dog muscle during reduced O2 delivery conditions. J Appl Physiol 1992; 73: 1662-70.
    CrossrefPubMedGoogle Scholar
  • 22 Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD. Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 1996; 80: 988-98.
    CrossrefPubMedGoogle Scholar