Subscribe to RSS
Download PDF
DOI: 10.1055/s-0038-1634930
Serum Lipid Values and Age in Healthy Women: A Preliminary Report on Cholesterol
The assistance of Yong Sohn, Research Student Fellow, Center for Preventive Medicine and Health Research, San Francisco State University, is gratefully acknowledged.
Publication History
Publication Date:
06 February 2018 (online)
Abstract:
In a 20-year prospective study of the influence of lifestyle and age on health parameters in men’s and women’s serum cholesterol, tryiglycerides and high density and low density lipoproteins were measured periodically to determine each person’s longitudinal profile. The accumulated data for 1008 women of 20 to 70 years is averaged by five-year age brackets. Scatter plots and simple regression of these five-year group means for ages 20 to 45 years, reveals a gradual increase in serum cholesterol, increasing from 176 mg/dl to 196 with a slope of 0.61 mg/dl per year. Between ages 45 and 70, the slope increases substantially to 1.91 mg/dl per year, and the five-year group means rise from 196 at age 45 to 239 at age 70 in rather uniform increments. The data have been analyzed for the other lipids and the relationship to estrogen replacement, nutritional, and exercise habits.
-
REFERENCES
- 1 Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Fremingham study. Ann Intern Med 1971; 74: 1-12.
- 2 Hale WE, Stewart RB, Marks RG. Haematological and biochemical laboratory values in an ambulatory elderly population: an analysis of the effects of age, sex and drugs. Age and Aging 1983; 12: 275-84.
- 3 Klorfajn I, Mizrahy O, Assa S. A Study on serum lipids of the elderly. J Gerontol 1978; 33: 48-51.
- 4 Waller KV, Ward KM, Rudmann SV. Serum lipids, lipoproteins and apolipoproteins in the healthy elderly. Lab Med 1992; 23: 109-14.
- 5 Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes, a 26-year follow-up of the Framingham population. Am Heart J 1986; 111: 383-90.
- 6 Williams GZ, Widdowson GM, Penton J. Individual characteristics of variation in time-series studies of healthy people. II. Difference in values for clinical chemical analytes in serum among demographic groups by age and sex. Clin Chem 1978; 24: 313-20.
- 7 Williams GZ, Harnly ME. Health status and health habits assessment. Med Inform 1982; 07: 197-207.
- 8 Williams GZ, Young DS, Stein MR, Cotlove E. Biological and analytic components of variation in long-term studies, laboratory procedures and estimation of analytic variance. Clin Chem 1970; 16: 1016-21.
- 9 Crunch Version 4, statistical package. Oakland CA: Crunch Software Corporation.;