Subscribe to RSS
DOI: 10.1055/s-0038-1633283
Chronischer Tinnitus
Eine neuropsychiatrische Erkrankung?Chronic tinnitus: are we dealing with a neuropsychiatric disorder?Publication History
eingegangen am:
01 April 2012
angenommen am:
16 July 2012
Publication Date:
02 February 2018 (online)

Zusammenfassung
Eine Geräuschwahrnehmung ohne externen akustischen Stimulus wird als Tinnitus bezeichnet. Besonders durch Begleiterkrankungen des affektiven Spektrums kann chronischer Tinnitus zur Reduktion der Lebensqualität führen. Es existiert derzeit kein “Königsweg” bei der Behandlung von Tinnitus, jedoch sollte dies keinen Anlass zur Hilflosigkeit auf Seiten des Therapeuten darstellen. Vielmehr sind allgemeine therapeutische Optionen verfügbar, welche sich mit geringem Aufwand in die tägliche Praxis integrieren lassen. Behandlungsansätze erstrecken sich vom beratenden therapeutischen Gespräch über kognitive Verhaltenstherapie, Neurofeedback-Methoden und neuromodulatorischen Techniken bis hin zur pharmakologischen Behandlung, die besonders bei tinnitusassoziierten Symptomen wie Schlafund Konzentrationsstörungen indiziert sein kann. Aufgrund der zunehmenden Evidenz für die Beteiligung zentralnervöser Strukturen an der Pathogenese von chronischem Tinnitus sowie der hohen Komorbidität mit genuin psychiatrischen Krankheitsbildern, wie Depression und Angsterkrankungen, bestehen gute Gründe für Nervenärzte, sich eingehender mit Tinnitus zu beschäftigen.
Summary
Tinnitus is the perception of sound in absence of any external acoustic stimuli. It may lead to significant reductions of quality of life especially by affective comorbidities. Tinnitus is difficult to treat but this should not lead to feelings of helplessness in therapists. In contrary, there is a multitude of general treatment options at hand which can be integrated in daily therapeutic routine quite easily. General treatment options for chronic tinnitus range from counseling, cognitive behavioral therapy, neurofeedback and neuromodulatory techniques to pharmacological treatment, which may especially be suitable in targeting tinnitus-associated symptoms like sleeping disorders and attentional deficits. Awareness of psychiatrists and neurologist about tinnitus is considered to be vital both because of the growing evidence for a decisive role of the central nervous system in the pathophysiology of chronic tinnitus and its comorbid associations with neuropsychiatric core symptoms like depressive disorders and anxiety.
-
Literatur
- 1 Bauer CA. et al. Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma. J Neurosci Res 2008; 86 (11) 2564-78.
- 2 Eggermont JJ, Roberts LE. The neuroscience of tinnitus. Trends Neurosci 2004; 27 (11) 676-82.
- 3 Kaltenbach JA. The dorsal cochlear nucleus as a contributor to tinnitus: mechanisms underlying the induction of hyperactivity. Prog Brain Res 2007; 166: 89-106.
- 4 Melcher JR. et al. Lateralized tinnitus studied with functional magnetic resonance imaging: abnormal inferior colliculus activation. J Neurophysiol 2000; 83 (02) 1058-72.
- 5 Moller AR. The role of neural plasticity in tinnitus. Prog Brain Res 2007; 166: 37-45.
- 6 Roberts LE. et al. Ringing ears: the neuroscience of tinnitus. J Neurosci 2010; 30 (45) 14972-9.
- 7 Engineer ND. et al. Reversing pathological neural activity using targeted plasticity. Nature 2011; 470 (7332): 101-4.
- 8 Schlee W. et al. Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci 2009; 10: 11.
- 9 Zenner HP. Beethovens Taubheit: “Wie ein Verbannter muß ich leben”. Dtsch Arztebl 2002; 99: A2762-2766.
- 10 De Ridder D. Textbook of Tinnitus. In: Moller A. (eds.). München: Springer 2011
- 11 Axelsson A, Ringdahl A. Tinnitus – a study of its prevalence and characteristics. Br J Audiol 1989; 23 (01) 53-62.
- 12 Hoffman H, Reed G. Epidemiology of Tinnitus. In: Snow JB. (ed.). Tinnitus: Theory and Management. London: BC Decker; 2004
- 13 Coles RR. Epidemiology of tinnitus: prevalence. J Laryngol Otol Suppl 1984; 09: 7-15.
- 14 Harter M. et al. [Psychological stress and impaired quality of life in patients with tinnitus]. HNO 2004; 52 (02) 125-31.
- 15 Hall DA. et al. Treatment options for subjective tinnitus: self reports from a sample of general practitioners and ENT physicians within Europe and the USA. BMC Health Serv Res 2011; 11: 302.
- 16 House JW, Brackmann DE. Tinnitus: surgical treatment. Ciba Found Symp 1981; 85: 204-16.
- 17 Zheng Y. et al. The effects of acoustic trauma that can cause tinnitus on spatial performance in rats. Neuroscience 2011; 186: 48-56.
- 18 Zheng Y. et al. The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats. Neuroscience 2011; 193: 143-53.
- 19 Eggermont JJ. Pathophysiology of tinnitus. Prog Brain Res 2007; 166: 19-35.
- 20 Norena AJ, Eggermont JJ. Enriched acoustic environment after noise trauma reduces hearing loss and prevents cortical map reorganization. J Neurosci 2005; 25 (03) 699-705.
- 21 Norena AJ. An integrative model of tinnitus based on a central gain controlling neural sensitivity. Neurosci Biobehav Rev 2011; 35 (05) 1089-109.
- 22 Schaette R, Kempter R. Development of tinnitusrelated neuronal hyperactivity through homeostatic plasticity after hearing loss: a computational model. Eur J Neurosci 2006; 23 (11) 3124-38.
- 23 Yang S. et al. Homeostatic plasticity drives tinnitus perception in an animal model. Proc Natl Acad Sci USA 2011; 108 (36) 14974-9.
- 24 Adjamian P, Sereda M, Hall DA. The mechanisms of tinnitus: perspectives from human functional neuroimaging. Hear Res 2009; 253 (1–2): 15-31.
- 25 Lanting CP, de Kleine E, van Dijk P. Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res 2009; 255 (1–2): 1-13.
- 26 Weisz N, Dohrmann K, Elbert T. The relevance of spontaneous activity for the coding of the tinnitus sensation. Prog Brain Res 2007; 166: 61-70.
- 27 Schlee W. et al. Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS One 2008; 03 (11) e3720.
- 28 van der Loo E. et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS One 2009; 04 (10) e7396.
- 29 De Ridder D. et al. Phantom percepts: Tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci USA 2011; 108 (20) 8075-80.
- 30 De Ridder D. et al. Amygdalohippocampal involvement in tinnitus and auditory memory. Acta Otolaryngol Suppl 2006; (556) 50-3.
- 31 Vanneste S. et al. The neural correlates of tinnitusrelated distress. Neuroimage 2010; 52 (02) 470-80.
- 32 Landgrebe M. et al. Neuronal correlates of symptom formation in functional somatic syndromes: a fMRI study. Neuroimage 2008; 41 (04) 1336-44.
- 33 Schlee W. et al. Mapping cortical hubs in tinnitus. BMC Biol 2009; 07: 80.
- 34 Langguth B. et al. Algorithm for the diagnostic and therapeutic management of tinnitus; in: Textbook of Tinnitus. Moller A. (ed.). München: Springer; 2011
- 35 Del Bo L. et al. Tinnitus aurium in persons with normal hearing: 55 years later. Otolaryngol Head Neck Surg 2008; 139 (03) 391-4.
- 36 Heller MF, Bergman M. Tinnitus aurium in normally hearing persons. Ann Otol Rhinol Laryngol 1953; 62 (01) 73-83.
- 37 Stobik C. et al. Evidence of psychosomatic influences in compensated and decompensated tinnitus. Int J Audiol 2005; 44 (06) 370-8.
- 38 Hiller W, Goebel G. Komorbidität psychiatrischer Störungen beim chronischen Tinnitus. In: Goebel G. (ed.). Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. München: Urban & Vogel; 2001
- 39 Somers J. et al. Prevalence and incidence studies of anxiety disorders: a systematic review of the literature. Can J Psychiatry 2006; 51 (02) 100-13.
- 40 Belli S. et al. Assessment of psychopathological aspects and psychiatric comorbidities in patients affected by tinnitus. Eur Arch Otorhinolaryngol 2008; 265 (03) 279-85.
- 41 Marciano E. et al. Psychiatric comorbidity in a population of outpatients affected by tinnitus. Int J Audiol 2003; 42 (01) 4-9.
- 42 Zoger S, Svedlund J, Holgers KM. The effects of sertraline on severe tinnitus suffering--a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2006; 26 (01) 32-9.
- 43 Baguley DM. Hyperacusis. J R Soc Med 2003; 96 (12) 582-5.
- 44 Gomes E, Pedroso FS, Wagner MB. Auditory hypersensitivity in the autistic spectrum disorder. Pro Fono 2008; 20 (04) 279-84.
- 45 Andersson G. et al. Hypersensitivity to sound (hyperacusis): a prevalence study conducted via the Internet and post. Int J Audiol 2002; 41 (08) 545-54.
- 46 Fabijanska A. et al. Epidemiology of tinnitus and hyperacusis in Poland. In: The Tinnitus and Hyperacusis Centre. Proceedings of the Sixth International Tinnitus Seminar. London: Hazelll JWP; 1999
- 47 Bauer CA, Brozoski TJ. Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. J Assoc Res Otolaryngol 2001; 02 (01) 54-64.
- 48 Hesser H. et al. systematic review and meta-analysis of randomized controlled trials of cognitive-behavioral therapy for tinnitus distress. Clin Psychol Rev 2011; 31 (04) 545-53.
- 49 Martinez-Devesa P. et al. Cognitive behavioural therapy for tinnitus. Cochrane Database Syst Rev 2010; (09) CD005233.
- 50 Dohrmann K. et al. Neurofeedback for treating tinnitus. Prog Brain Res 2007; 166: 473-85.
- 51 Elgoyhen AB, Langguth B. Pharmacological approaches to the treatment of tinnitus. Drug Discov Today 2010; 15 (7–8): 300-5.
- 52 Salvi R, Lobarinas E, Sun W. Pharmacology treatments for tinnitus: new and old. Drugs Future 2009; 34 (05) 381-400.
- 53 Schaette R. et al. Acoustic stimulation treatments against tinnitus could be most effective when tinnitus pitch is within the stimulated frequency range. Hear Res 2010; 269 (1–2): 95-101.
- 54 Van de Heyning P. et al. Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation. Ann Otol Rhinol Laryngol 2008; 117 (09) 645-52.
- 55 Hobson J, Chisholm E, El Refaie A. Sound therapy (masking) in the management of tinnitus in adults. Cochrane Database Syst Rev 2010; (12) CD006371.
- 56 Langguth B. et al. Transcranial magnetic stimulation for the treatment of tinnitus: effects on cortical excitability. BMC Neurosci 2007; 08: 45.
- 57 Langguth B. et al. rTMS for the treatment of tinnitus: the role of neuronavigation for coil positioning. Neurophysiol Clin 2010; 40 (01) 45-58.
- 58 Kleinjung T. et al. Transcranial magnetic stimulation: a new diagnostic and therapeutic tool for tinnitus patients. Int Tinnitus J 2008; 14 (02) 112-8.
- 59 Cheung SW, Larson PS. Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC). Neuroscience 2010; 169 (04) 1768-78.
- 60 Shi Y. et al. Deep brain stimulation effects in patients with tinnitus. Otolaryngol Head Neck Surg 2009; 141 (02) 285-7.
- 61 De Ridder D. et al. Electrical stimulation of auditory and somatosensory cortices for treatment of tinnitus and pain. Prog Brain Res 2007; 166: 377-88.
- 62 Schnupp J. Auditory neuroscience: how to stop tinnitus by buzzing the vagus. Curr Biol 2011; 21 (07) R263-5.
- 63 Hoare DJ. et al. Systematic review and meta-analyses of randomized controlled trials examining tinnitus management. Laryngoscope 2011; 121 (07) 1555-64.
- 64 Hoare DJ, Hall DA. Clinical guidelines and practice: a commentary on the complexity of tinnitus management. Eval Health Prof 2011; 34 (04) 413-20.
- 65 Searchfield G. A commentary on the complexity of tinnitus management: clinical guidelines provide a path through the fog. Eval Health Prof 2011; 34 (04) 421-8.
- 66 Del Bo L, Ambrosetti U. Hearing aids for the treatment of tinnitus. Prog Brain Res 2007; 166: 341-5.
- 67 Searchfield GD. Hearing Aids and Tinnitus. In: Tinnitus Treatment. Tyler R. (ed.). Stuttgart: Thieme 2007
- 68 Surr RK, Montgomery AA, Mueller HG. Effect of amplification on tinnitus among new hearing aid users. Ear Hear 1985; 06 (02) 71-5.
- 69 Moffat G. et al. Effects of hearing aid fitting on the perceptual characteristics of tinnitus. Hear Res 2009; 254 (1–2): 82-91.
- 70 Melin L. et al. Hearing aids and tinnitus – an experimental group study. Br J Audiol 1987; 21 (02) 91-7.
- 71 Norena A. et al. Psychoacoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neurootol 2002; 07 (06) 358-69.
- 72 Stracke H, Okamoto H, Pantev C. Customized notched music training reduces tinnitus loudness. Commun Integr Biol 2010; 03 (03) 274-7.
- 73 Okamoto H. et al. Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity. Proc Natl Acad Sci USA 2010; 107 (03) 1207-10.
- 74 Tass PA, Hauptmann C. Therapeutic modulation of synaptic connectivity with desynchronizing brain stimulation. Int J Psychophysiol 2007; 64 (01) 53-61.
- 75 Tass PA. et al. Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restor Neurol Neurosci. 2012 Mar 13, E-Pub ahead of print.
- 76 Tass PA, Popovych OV. Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling. Biol Cybern 2012; 106 (01) 27-36.
- 77 Jastreboff PJ. Tinnitus retraining therapy. Prog Brain Res 2007; 166: 415-23.
- 78 Henry JA. et al. Outcomes of clinical trial: tinnitus masking versus tinnitus retraining therapy. J Am Acad Audiol 2006; 17 (02) 104-32.
- 79 Herraiz C. et al. Long-term clinical trial of tinnitus retraining therapy. Otolaryngol Head Neck Surg 2005; 133 (05) 774-9.
- 80 Phillips JS, McFerran D. Tinnitus Retraining Therapy (TRT) for tinnitus. Cochrane Database Syst Rev 2010; (03) CD007330.
- 81 Flor H. et al. Auditory discrimination training for the treatment of tinnitus. Appl Psychophysiol Biofeedback 2004; 29 (02) 113-20.
- 82 Herraiz C, Diges I, Cobo P. Auditory discrimination therapy (ADT) for tinnitus management. Prog Brain Res 2007; 166: 467-71.
- 83 Roberts LE, Bosnyak DJ. Auditory Training in Tinnitus. In: Textbook of Tinnitus. Moller A, et al. (eds.). New York: Springer; 2011
- 84 Searchfield GD, Morrison-Low J, Wise K. Object identification and attention training for treating tinnitus. Prog Brain Res 2007; 166: 441-60.
- 85 Crocetti A, Forti S, Del Bo L. Neurofeedback for subjective tinnitus patients. Auris Nasus Larynx 2011; 38 (06) 735-8.
- 86 Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet 1985; 01 (8437): 1106-7.
- 87 Ridding MC, Rothwell JC. Is there a future for therapeutic use of transcranial magnetic stimulation?. Nat Rev Neurosci 2007; 08 (07) 559-67.
- 88 Hallett M. Transcranial magnetic stimulation and the human brain. Nature 2000; 406 (6792): 147-50.
- 89 Gerschlager W, Siebner HR, Rothwell JC. Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex. Neurology 2001; 57 (03) 449-55.
- 90 Langguth B. et al. Controversy: Does repetitive transcranial magnetic stimulation/ transcranial direct current stimulation show efficacy in treating tinnitus patients?. Brain Stimul 2008; 01 (03) 192-205.
- 91 Plewnia C. Brain stimulation: new vistas for the exploration and treatment of tinnitus. CNS Neurosci Ther 2011; 17 (05) 449-61.
- 92 Kleinjung T. et al. Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: a pilot study. Otolaryngol Head Neck Surg 2008; 138 (04) 497-501.
- 93 Kreuzer PM. et al. Can temporal repetitive transcranial magnetic stimulation be enhanced by targeting affective components of Tinnitus with frontal rTMS? A randomized controlled pilot trial. Front Syst Neurosci 2011; 05: 88.
- 94 Faber M. et al. Top down prefrontal affective modulation of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul y2011. Oct 5; E-pub ahead of print.
- 95 Frank ETB. et al. Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study. J Neurol 2012; 259 (02) 327-33.
- 96 Garin P. et al. Shortand long-lasting tinnitus relief induced by transcranial direct current stimulation. J Neurol 2011; 258 (11) 1940-8.
- 97 Vanneste S. et al. Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study. Exp Brain Res 2010; 202 (04) 779-85.
- 98 Miranda PC, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol 2006; 117 (07) 1623-9.
- 99 Nitsche MA. et al. Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. Clin Neurophysiol 2003; 114 (04) 600-4.
- 100 Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 2001; 57 (10) 1899-901.
- 101 Moller AR. A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. Am J Otol 1997; 18 (02) 268-9.
- 102 Israel JM. et al. Lidocaine in the treatment of tinnitus aurium. A double-blind study. Arch Otolaryngol 1982; 108 (08) 471-3.
- 103 Melding PS, Goodey RJ, Thorne PR. The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. J Laryngol Otol 1978; 92 (02) 115-21.
- 104 Trellakis S, Lautermann J, Lehnerdt G. Lidocaine: neurobiological targets and effects on the auditory system. Prog Brain Res 2007; 166: 303-22.
- 105 Darlington CL, Smith PF. Drug treatments for tinnitus. Prog Brain Res 2007; 166: 249-62.
- 106 Robinson SK. et al. Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. Psychosom Med 2005; 67 (06) 981-8.
- 107 Sullivan M. et al. A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. Arch Intern Med 1993; 153 (19) 2251-9.
- 108 Bayar N. et al. Efficacy of amitriptyline in the treatment of subjective tinnitus. J Otolaryngol 2001; 30 (05) 300-3.
- 109 Robinson S. Antidepressants for treatment of tinnitus. Prog Brain Res 2007; 166: 263-71.
- 110 Hoekstra CE. et al. Anticonvulsants for tinnitus. Cochrane Database Syst Rev 2011; (07) CD007960.
- 111 Levine RA. Typewriter tinnitus: a carbamazepineresponsive syndrome related to auditory nerve vascular compression. ORL J Otorhinolaryngol Relat Spec 2006; 68 (01) 43-6.
- 112 Mardini MK. Ear-clicking “tinnitus” responding to carbamazepine. N Engl J Med 1987; 317 (24) 1542.
- 113 Azevedo AA, Figueiredo RR. Treatment of tinnitus with acamprosate. Prog Brain Res 2007; 166: 273-7.
- 114 Sharma DK. et al. Role of acamprosate in sensorineural tinnitus. Indian J Pharmacol 2012; 44 (01) 93-6.
- 115 Denk DM. et al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol 1997; 117 (06) 825-30.
- 116 Domeisen H, Hotz MA, Hausler R. Caroverine in tinnitus treatment. Acta Otolaryngol 1998; 118 (04) 606-8.
- 117 Figueiredo RR. et al. Tinnitus treatment with memantine. Otolaryngol Head Neck Surg 2008; 138 (04) 492-6.
- 118 Suckfull M. et al. A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC Ear Nose Throat Disord 2011; 11: 1.
- 119 Elgoyhen AB. et al. Tinnitus: network pathophysiology-network pharmacology. Front Syst Neurosci 2012; 06: 1.