The Influence of Intratendinous Sodium Hyaluronate on Tendon Healing in Horses

L. J. Gift; E. M. Gaughan; R. M. DeBowes; J. P. Douglass; R. K. Frank; R. D. Klemm

doi:10.1055/s-0038-1633108

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 1992; 05(04): 151-157
DOI: 10.1055/s-0038-1633108

Original Research

Schattauer GmbH

The Influence of Intratendinous Sodium Hyaluronate on Tendon Healing in Horses

Authors

L. J. Gift

¹Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
E. M. Gaughan

¹Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
R. M. DeBowes

¹Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
J. P. Douglass

²Department of Anatomy, Physiology, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
R. K. Frank

³Department of Veterinary Diagnosis, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
R. D. Klemm

⁴Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA

Abstract

Summary

Acute tendinitis was created bilaterally in the mid-metacarpal region of the deep digital flexor tendons of six horses with intratendinous collagenase administration. The collagenase-induced lesion in one deep digital flexor tendon of each horse was injected 48 h later with 10.0 mg of sodium hyaluronate (1.0 ml) while employing ultrasound guidance. To serve as a control, the lesion in the contralateral deep digital flexor tendon was injected with 1.0 ml of 0.9% sodium chloride. Sequential ultra-sonographic examinations revealed that the sodium hyaluronate treated deep digital flexor tendons were significantly less enlarged and the collagenase-induced tendon lesions significantly smaller than control tendons and tendon lesions. Difference could not be detected between sodium hyaluronate treated tendons and control tendons using histological and video-interactive planar morphometric evaluation six weeks after treatment.

Collagenase-induced tendinitis lesions were treated with intratendinous administration of sodium hyaluronate in six horses. The size of the tendon lesions and the amount of tendon enlargement were significantly less in the sodium hyaluronate treated tendons compared to control tendons. A significant difference in the rate or quality of healing was not detected in the sodium hyaluronate treated tendons.

Keywords

Tendinitis - intratendinous sodium hyaluronate - hyaluronic acid

Full Text

References

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