The Effects of Polysulfated Glycosaminoglycan (Adeqtiail®) on Activated Partial Thromboplastin Time, Prothrombin Time, Complete Blood Count, Biochemical Profile and Urinalysis in Cats

J. J. de Haan; B. S. Beale; R. M. Clemmons; Laura Clark

doi:10.1055/s-0038-1633046

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 1994; 07(01): 77-81
DOI: 10.1055/s-0038-1633046

Original Research

Schattauer GmbH

The Effects of Polysulfated Glycosaminoglycan (Adeqtiail^®) on Activated Partial Thromboplastin Time, Prothrombin Time, Complete Blood Count, Biochemical Profile and Urinalysis in Cats

J. J. de Haan

¹From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Florida, USA

,

B. S. Beale

¹From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Florida, USA

,

R. M. Clemmons

¹From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Florida, USA

,

Laura Clark

¹From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Florida, USA

› Author Affiliations

Abstract

Summary

The effects of a single intramuscular administration of polysulfated glycosaminoglycan (PSGAG, Adequan^®a) on activated partial thromboplastin time (APTT), prothrombin time (PT), complete blood count (CBC), biochemical profile and urinalysis were determined in six adult cats. An injection of 5 mg/kg of PSGAG was given to three of the cats, and an injection of 25 mg/kg was given to the other three cats. Following a seven-day crossover interval, the doses were reversed. Serial blood and urine samples were collected over a 48-hour period after each injection. Administration of PSGAG resulted in a transient, dose-dependent increase of APTT and PT. Prolonged bleeding from the venipuncture sites in the 25 mg/kg group was observed. Some of the CBC, biochemical profile, and urinalysis values changed following treatment, but clinically significant adverse reactions were not noticed.

Polysulfated glycosaminoglycan (Adequan^®) is a heparin analogue with chondroprotective and anticoagulant properties. A single intramuscular injection of 5 mg/kg and 25 mg/kg of polysulfated glycosaminoglycan in six healthy adult cats resulted in a transient, dose-dependent increase of activated partial thromboplastin time and prothrombin time. Minor changes were seen on complete blood count, biochemical profile and urinalysis.

Keywords

Adequan^® - polysulfated glycosaminoglycan - feline - systemic effects

Full Text

References

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