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Vet Comp Orthop Traumatol 2006; 19(02): 106-109
DOI: 10.1055/s-0038-1632983
Brief Communication
Schattauer GmbH

Inclusion of marbofloxacin in PMMA orthopaedic cement

An in vitro experimental study
M. Cariou
1   Department of Small Animal Surgery
,
H. J. Boulouis
2   Department of Microbiology, Ecole Nationale Vétérinaire de Maisons-Alfort, Paris, France
,
P. Moissonnier
1   Department of Small Animal Surgery
› Author Affiliations
Further Information

Publication History

Received 19 July 2005

Accepted 03 December 2005

Publication Date:
08 February 2018 (online)

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Summary

This in vitro experimental study investigated the feasibility for marbofloxacin, a veterinary fluoroquinolone antibiotic, to retain its antibacterial activity after its inclusion in polymethylmethacrylate (PMMA) cement. The assays were conducted on gelose cultures of various types of bacteria isolated from canine spontaneous osteomyelitis. The efficiency of the antibiotics was assessed by using an antibiogram method. Resistance of marbofloxacin to the temperature observed during PMMA polymerization, antimicrobial effect of galenic, useful concentrations and comparison with gentamicin (reference antibiotic for this use) were evaluated. Marbofloxacin retained its antimicrobial activity after being heated to high temperatures reached during polymerization. The more effective galenic form to incorporate into the PMMA monomer was the marbofloxacin powder and the appropriate concentration was 1/40°. In this experiment, marbofloxacin included in PMMA showed a good antimicrobial activity; however this activity was lower than gentamicin added to PMMA on Gram + and Pseudomonas bacteria.Therefore, it seems useful to incorporate marbofloxacin to PMMA cement to treat, or to prevent, osteomyelitis associated with marbofloxacin sensitive bacteria.Nevertheless, the development of a marbofloxacin-PMMA cement requires further evaluation, especially pharmacological, biomechanical and clinical.

Keywords

Polymethylmethacrylate - marbofloxacin - osteomyelitis - orthopaedic cement
 

  • References

  • 1 Daly WR. Orthopaedic infections. In: Textbook of Small Animal Surgery. Slatter DH. ed Philadelphia: Saunders WB,; 1985: 2020-30.
    Search in Google Scholar
  • 2 Buchholz HW, Elson RA, Heinart K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop 1984; 190: 96-108.
    PubMedSearch in Google Scholar
  • 3 Welch AB. Antibiotics in acrylic bone cement, ' in vitro' studies. J Biomed Mater Res 1978; 12: 679-700.
    CrossrefPubMedSearch in Google Scholar
  • 4 Giraud Boulet B. Marbocyl, livre de référence sur la marbofloxacine. Paris: Laboratoires Vétoquinol; 1999
    Search in Google Scholar
  • 5 Lautenschlager EP, Jacobs JJ, Marshall GW. et al. Mechanical properties of bone cements containing large doses of antibiotic powders. J Biomed Res 1976; 6: 929-38.
    PubMedSearch in Google Scholar