The Role of the Interaction between Fe(III) and Cell Surface in the Accumulation of ⁶⁷Ga by Tumor Cells

The study of the interaction between complexed iron and tumor cells in the presence of ⁶⁷Ga-citrate indicates that a phenomenon of iron-binding related to the thermodynamic constant of stability of the iron complex, and a hydrolysis (or anion penetration) of the interaction product determine the uptake of ⁶⁷Ga. The effects of various parameters such as ionic composition of the medium, nature of the iron complex, time of incubation and number of cells are discussed.

Zusammenfassung

Die Untersuchung der Wechselwirkung zwischen einem Eisenkomplex und Tumorzellen in Gegenwart von ⁶⁷Ga weist darauf hin, daß ein Phänomen der Eisenbindung, das in Beziehung zur thermodynamischen Stabilitätskonstante des Eisenkomplexes steht, und eine Hydrolyse (oder Anionenpenetration) des Wechselwirkungsprodukts die Aufnahme des ⁶⁷Ga bestimmen. Die Effekte verschiedener Parameter wie Ionenzusammensetzung des Mediums, Art des Eisenkomplexes, Dauer der Inkubation und Anzahl der Zellen warden besprochen.

^* Biochemistry Department, University of Soria, Spain.

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