Rezidivierende Staphylococcus aureus- Infektionen

Christian Theilacker; Siegbert Rieg; Johannes Hübner; Winfried V. Kern

doi:10.1055/s-0038-1628955

Kinder- und Jugendmedizin, Table of Contents

Kinder- und Jugendmedizin 2008; 08(02): 101-104
DOI: 10.1055/s-0038-1628955

Infektiologie

Schattauer GmbH

Rezidivierende Staphylococcus aureus- Infektionen

Recurrent Staphylococcus aureus infections

Authors

Christian Theilacker

¹Abteilung Infektiologie, Medizin II, Universitätsklinik Freiburg (Leiter: Prof. Dr. med. Winfried V. Kern)
Siegbert Rieg

¹Abteilung Infektiologie, Medizin II, Universitätsklinik Freiburg (Leiter: Prof. Dr. med. Winfried V. Kern)
Johannes Hübner

¹Abteilung Infektiologie, Medizin II, Universitätsklinik Freiburg (Leiter: Prof. Dr. med. Winfried V. Kern)
Winfried V. Kern

¹Abteilung Infektiologie, Medizin II, Universitätsklinik Freiburg (Leiter: Prof. Dr. med. Winfried V. Kern)

Abstract

Zusammenfassung

Rezidive bei S. aureus-Infektionen sind häufig. Wirtsfaktoren, erregerspezifische Pathogenitätsfaktoren, aber auch eine inadäquate Therapie sind hierfür verantwortlich. Sie betreffen Haut- und Weichteilinfektionen ebenso wie Bakteriämien und sind von besonderer Bedeutung bei nichtentfernten oder -entfernbaren Fremdkörpern. Biofilmbildung und sogenannte Small Colony Variants spielen eine wichtige pathogenetische Rolle durch die Induktion von Resistenz gegenüber Antibiotika und körpereigenen antimikrobiellen Substanzen. Eine hoch dosierte Betalaktam- Therapie und ausreichende Therapiedauer sind für gute Behandlungsergebnisse wichtige Faktoren. Eine sorgfältige diagnostische Abklärung von Organabsiedelungen senkt die Rezidivrate der S. aureus-Bakteriämie.

Summary

Recurrent S. aureus infections are a frequent clinical problem. Host factors, virulence factors and inadequate medical therapy may be involved in recurrence of the infection. Skin and soft tissue, bloodstream and foreign body infections account most frequently for recurrent staphylococcal disease. In the setting of biofilm and small colony variants increased resistance against antibiotics as well as endogenous antimicrobial peptides is encountered. Adequate dosage and duration of the antimicrobial and preferred usage of beta lactams improves patient outcome. A thorough diagnostic workup to detect deep seated infection reduces the rate of recurrence in S. aureus bacteremia.

Schlüsselwörter

Staphylococcus aureus - Rezidiv - Bakteriämie - Fremdkörperinfektion

Keywords

Staphylococcus aureus - recurrence - bacteremia - foreign body infection

Full Text

References

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