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Nuklearmedizin 1987; 26(02): 93-96
DOI: 10.1055/s-0038-1628870
Review Articles
Schattauer GmbH

The Sensitivity of Radionuclide and Thermodilution Techniques to Detect Cardiac Dysfunction in the Baboon Model During Prolonged Anaesthesia

Die Sensitivität von Radionuklid- und Thermodilutionstechniken zur Erkennung kardialer Dysfunktion im Pavian-Modell während einer längeren Anästhesie
Irene C. Dormehl
1   From the AEC Institute for Life Sciences, Oklahoma City, USA
,
H. Bosman
2   University of Pretoria, the H. A. Grové Animal Research Centre, Oklahoma City, USA
,
J. P. Pretorius
3   H. F. Verwoerd Hospital, Pretoria, the Dept, of Surgery, , Oklahoma City, USA
,
M. Wilson
4   Medical School, University of Pretoria, South Africa, and the Veterans Administration Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City, USA
,
R. Burow
4   Medical School, University of Pretoria, South Africa, and the Veterans Administration Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City, USA
,
L. Patterson
2   University of Pretoria, the H. A. Grové Animal Research Centre, Oklahoma City, USA
,
M. Maree
1   From the AEC Institute for Life Sciences, Oklahoma City, USA
,
N. Hugo
1   From the AEC Institute for Life Sciences, Oklahoma City, USA
,
C. van Zandwijk
1   From the AEC Institute for Life Sciences, Oklahoma City, USA
,
C. van Vuuren
1   From the AEC Institute for Life Sciences, Oklahoma City, USA
,
G. Vermaak
2   University of Pretoria, the H. A. Grové Animal Research Centre, Oklahoma City, USA
› Author Affiliations
Further Information

Publication History

Received: 26 November 1986

Publication Date:
04 February 2018 (online)

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This study was undertaken to evaluate the fluctuations of cardiac parameters in a baboon model during pentobarbitone anaesthesia which will serve as a baseline control for shock studies. Thermodilution and radionuclide methods were used to determine cardiac parameters. Radionuclide studies were repeated without any cardiac catheters to assess the effect of these on cardiac performance. The results represent baseline fluctuations in cardiac parameters against which cardiac dysfunction can be diagnosed in shock studies. The results also indicate that cardiac catheterisation does not affect cardiac performance significantly.

Zusammenfassung

Diese Studie wurde unternommen, um Fluktuationen kardialer Parameter in einem Pavian-Modell unter Pentobarbital-Narkose, das als Basiskontrolle für Schockstudien dienen soll, zu bewerten. Thermodilutions- und Radionuklid-Untersuchungen wurden ohne jeglichen Katheter wiederholt, um deren Einfluß auf die Herzfunktion zu beurteilen. Die Ergebnisse repräsentieren Basisfluktuationen der kardialen Parameter, denen gegenüber eine kardiale Dysfunktion unter Schockbedingungen abgegrenzt werden kann. Die Ergebnisse belegen auch, daß Herzkatheter die kardiale Funktion nicht wesentlich beeinflussen.

Researchers adhered to ethical guidelines as layed down by the veterinary authorities of the Research* Institute.


 

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