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Nervenheilkunde 2009; 28(10): 683-688
DOI: 10.1055/s-0038-1627145
DOI: 10.1055/s-0038-1627145
Nuklearmedizinische Bildgebung
Nuklearmedizinische Diagnostik in der Neuroonkologie
Nuclear medicine diagnostics in neurooncologyFurther Information
Publication History
Eingegangen am:
10 June 2009
angenommen am:
07 June 2009
Publication Date:
19 January 2018 (online)
Zusammenfassung
Die Beurteilung der Ausdehnung von Hirntumoren, die Abschätzung der Prognose und die Rezidivdiagnostik stellen auch im Zeitalter der Magnetresonanztomografie (MRT) noch wichtige Herausforderungen in der neuroonkologischen Diagnostik dar. Nuklearmedizinische Verfahren unter Verwendung der Positronen- Emissions-Tomografie (PET) und Single- Photonen-Emissions-Computertomografie (SPECT) können einen wesentlichen Beitrag leisten. So ermöglichen die PET und SPECT mit radioaktiv markierten Aminosäuren eine optimierte Darstellung der Ausdehnung von zerebralen Gliomen, was bei der Probeentnahme, der Planung einer Operation und einer Bestrahlung hilfreich sein kann. Außerdem können mit verschiedenen Tracern Tumorrezidive von posttherapeutischen Veränderungen besser differenziert werden sowie Hinweise auf den Malignitätsgrad und die Prognose von Hirntumoren gewonnen werden.
Summary
The diagnostic assessment of tumor extent, grading and detection of recurrence of brain tumors remains a challenge in the era of magnetic resonance imaging (MRI). Positron emission tomography (PET) and single photon emission computed tomography (SPECT) may provide relevant additional information which allow more accurate diagnostics in unclear situations. Especially, PET and SPECT studies using radiolabeled amino acids offer a better delineation of cerebral gliomas which helps to guide biopsies, to plan surgical interventions and radiation therapy. Additionally, several radiotracers help to differentiate tumor recurrence from unspecific post-therapeutic changes in brain tissue and provide information on histological grading and prognosis of brain tumors.
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