Genetik affektiver Störungen

Zusammenfassung

Die Anwendung molekulargenetischer Methoden auf die genetisch mitbedingten affektiven Störungen erbrachte in den vergangenen Jahren die ersten, zum Erkrankungsrisiko beitragenden Genorte sowie die ersten sehr wahrscheinlichen Suszeptibilitätsgene. Der Erkenntnisfortschritt ist gleichwohl vor allem bei unipolaren Depressionen relativ langsam, was wahrscheinlich mit der Unschärfe und Heterogenität des Phänotyps und mit Gen-Umgebungs-Interaktionen zusammenhängt. Die biometrische Analyse familiärer Häufungsmuster bleibt notwendig, um für molekulargenetische Analysen geeignete Phänotypen zu finden.

Summary

The application of molecular-genetic techniques to the genetically influenced affective disorders is elucidating the genetic architecture:a series of gene loci as well as very likely susceptibility genes are now identified. Yet, progress is particularly slow for unipolar depression. Reasons are the uncertainty and heterogeneity of the phenotype definitions and underlying gene-environment interactions. Biometrical analyses of the observed patterns of the familial aggregation of symptoms and endophenotypes are further necessary to identify phenotypes which are particularly appropriate for molecular-genetic analysis.

Schlüsselwörter

Bipolare Störungen - unipolare Depression - Genetik

Keywords

Bipolar disorders - unipolar depression - genetics

• Literatur

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