Schlaf, Table of Contents Schlaf 2013; 2(04): 228-233DOI: 10.1055/s-0038-1626070 KASUISTIK Akromegalie & Schlaf Schattauer GmbH Schlafbezogene Atmungsstörung bei Akromegalie Sebastian Böing 1 Krankenhaus Bethanien Aufderhöher Str. 169–175 42699 Solingen, Email: Sebastian.Boeing@klinik-bethanien.de› Author AffiliationsRecommend Article Abstract Buy Article Schlafbezogene Atmungsstörungen sind eine häufige und klinisch relevante Komplikation bei Patienten mit Akromegalie. In Zusammenschau mit Akromegalie-verdächtigen anatomischen Auffälligkeiten können sie wichtiger Weichensteller für eine weitere endokrinologische Diagnostik sein. Wir berichten den Kasus eines Patienten, dessen schlafmedizinische Vorstellung zur Diagnosestellung einer Akromegalie führte. Full Text References Literatur 1 Holdaway IM, Rajasoorya C. Epidemiology of acromegaly. Pituitary 1999; 2: 29-41. 2 Chanson P, Salenave S. Acromegaly. Orphanet Journal of Rare Diseases. 2008; 3: 17. 3 Hernandez-Gordillo D, Ortega-Gomez Mdel R, Galicia-Polo L. et al. Sleep apnea in patients with acromegaly. Frequency, characterization and positive pressure titration. The open respiratory medicine journal 2012; 6: 28-33. 4 Weiss V, Sonka K, Pretl M. et al. Prevalence of the sleep apnea syndrome in acromegaly population. J Endocrinol Invest 2000; 23: 515-519. 5 Kashine S, Kishida K, Funahashi T, Shimomura I. Characteristics of sleep-disordered breathing in Japanese patients with acromegaly. Endocr J 2012; 59: 31-38. 6 Nabarro JD. Acromegaly. Clin Endocrinol (Oxf) 1987; 26: 481-512. 7 van Haute FR, Taboada GF, Correa LL. et al. Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging. Eur J Endocrinol 2008; 158: 459-465. 8 Hochban W, Ehlenz K, Conradt R, Brandenburg U. Obstructive sleep apnoea in acromegaly: the role of craniofacial changes. Eur Respir J 1999; 14: 196-202. 9 Colao A, Ferone D, Marzullo P, Lombardi G. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocrine reviews 2004; 25: 102-152. 10 Grunstein RR, Ho KY, Berthon-Jones M, Stewart D, Sullivan CE. Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. Am J Respir Crit Care Med 1994; 150: 496-502. 11 Berry RB, Budhiraja R, Gottlieb DJ. et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012; 8: 597-619. 12 Douglas NJ, White DP, Pickett CK, Weil JV, Zwillich CW. Respiration during sleep in normal man. Thorax 1982; 37: 840-844. 13 Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP. Pathophysiology of sleep apnea. Physiological reviews 2010; 90: 47-112. 14 Douglas NJ, White DP, Weil JV. et al. Hypoxic ventilatory response decreases during sleep in normal men. Am Rev Respir Dis 1982; 125: 286-289. 15 Douglas NJ, White DP, Weil JV, Pickett CK, Zwillich CW. Hypercapnic ventilatory response in sleeping adults. Am Rev Respir Dis 1982; 126: 758-762. 16 Dingli K, Fietze I, Assimakopoulos T. et al. Arousability in sleep apnoea/hypopnoea syndrome patients. Eur Respir J 2002; 20: 733-740. 17 S3-Leitlinie: Nicht erholsamer Schlaf/Schlafstörungen: Deutsche Gesellschaft für Schlafforschung und Schlafmedizin (DGSM). 2009 18 Attal P, Chanson P. Endocrine aspects of obstructive sleep apnea. J Clin Endocrinol Metab 2010; 95: 483-495. 19 Davi MV, Dalle Carbonare L, Giustina A. et al. Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease. Eur J Endocrinol 2008; 159: 533-540.
