Tierarztl Prax Ausg G Grosstiere Nutztiere 2008; 36(03): 189-198
DOI: 10.1055/s-0038-1624034
Schwein
Schattauer GmbH

Nichtpuerperale Uterusentzündungen beim Schwein[*]

Eine ÜbersichtNon-puerperal inflammations of the uterus in the pigA review
J. Kauffold
1   Department for Clinical Studies (Direktor: Prof. G. C. Althouse), New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
› Author Affiliations
Further Information

Publication History

Eingegangen: 01 April 2008

akzeptiert: 10 April 2008

Publication Date:
05 January 2018 (online)

Zusammenfassung:

Nichtpuerperale Uterusentzündungen sind beim Schwein weit verbreitet und ein bedeutender Grund für Infertilität. Da es bis heute weder eine klinische noch eine histopathologische Nomenklatur gibt, wird der Versuch einer Systematisierung unternommen. Verfügbare Daten zu Ätiologie und Pathogenese werden präsentiert und Klinik, Diagnostik, Therapie, Prävention als auch prädisponierende Faktoren beschrieben. Die nichtpuerparele Uterusentzündung sollte stärker als autonome Krankheit wahrgenommen werden. Dabei wird folgende Differenzierung vorgeschlagen: zum einen die klinische nichtpuerperale Endometritis mit adspektorisch und/oder vaginoskopisch feststellbarem uterinem Ausfluss und/oder sonographischen Abnormalitäten, zum anderen die subklinische Form, bei der diese Befunde fehlen. Es ist anzunehmen, dass vor allem chronische Endometritiden subklinisch verlaufen, während akute und subakute Endometritiden mehr oder weniger deutlich klinisch auffallen.

Summary:

Non-puerperal inflammations of the uterus are common in pigs and a significant reason for infertility. However, since there is still no clinical or histopathological nomenclature, an attempt of systematization is made. Available data on etiology and pathogenesis are presented. Clinical course, diagnostics, therapy, prevention and predisposing factors are described. It is necessary to increase the awareness of the nonpuerperal inflammation of the uterus as an autonomous disease. It is recommended to distinguish between clinical non-puerperal endometritis, apparent on the basis of uterine discharge detected by observation or vaginal inspection and/or sonographical uterine abnormalities, and sub-clinical endometritis lacking any of the mentioned symptoms. It is assumed that it is predominately the chronic endometritis that is sub-clinical, while the acute and sub-acute endometritis is more or less clinically apparent.

* Herrn Prof. Dr. Dr. h. c. mult. Hartwig Bostedt zum 70. Geburtstag gewidmet.


 
  • Literatur

  • 1 Alexopoulos C, Fthenakis GC, Burriel A, Bourtzi-Hatopoulou E, Kritas SK, Sbiraki A, Kyriakis SC. The effects of the periodical use of in-feed chlortetracycline on the reproductive performance of gilts and sows of a commercial pig farm with a history of clinical and subclinical viral and bacterial infections. Reprod Dom Anim 2003; 38: 187-192.
  • 2 Almond GW, Bosu WTK, King GJ. The Not-In-Pig (NIP) Sow. Proc 10th ICAR, Urbana-Champaign Illinois, USA: 1984: 441-443.
  • 3 Almond GW, Flowers WL, Batista L, D’Allaire S. Diseases of the reproductive system. In: Diseases of Swine, 9th ed. Straw BE, D’Allaire Mengeling WL, Taylor DJ. eds. Ames, Iowa, USA: Blackwell; 2006: 113-147.
  • 4 Almond GW. Clinical examination of female reproductive organs. In: Current Therapy in Large Animal Theriogenology, 2nd ed. Youngquist RS, Threlfall WR. eds. St. Louis, Missouri, USA: Saunders Elsevier; 2007: 749-764.
  • 5 Althouse GC, Lu KG. Bacteriospermia in extended porcine semen. Theriogenology 2005; 63: 573-584.
  • 6 Althouse GC. Influence of extended semen quality on sow reproductive performance. Proc 4. Leipziger Tierärztekongress Leipzig, Deutschland: 2008: 560-562.
  • 7 Bange U. Immunofluorescence-microscopic, macroscopic, histological and bacteriological investigations of the ovaria and uteri of sows with propagative disorders with special consideration of the impact of chlamydiae. PhD dissertation. Faculty of Veterinary Medicine, University of Leipzig Leipzig: 2000
  • 8 Bara MR, McGowan MR, O’Boyle D, Cameron RD. A study of the microbial flora of the anterior vagina of normal sows during different stages of the reproductive cycle. Aus Vet 1993; 70: 256-259.
  • 9 Baumann B, Bilkei G. The effect of postpartal prostaglandin F2α application on some of the subsequent reproductive parameter of the sows with or without antepartal vulvovaginal discharge. The Pig Journal 2001; 47: 35-41.
  • 10 Bilkei G, Goos T. Evaluation of the occurrence of SUGD (Swine Urogenital Disease) in large pig production units. Proc 13th IPVS Congress Bangkok, Thailand: 1994: 472 (Abstract).
  • 11 Biksi I, Takacs N, Vetersi F, Fodor L, Szenci O, Fenyö E. Association between endometritis and urocystitis in culled sows. Acta Vet Hung 2002; 50: 413-423.
  • 12 Bostedt H. Ovarian imbalance in swine. Tierärztl Prax 1988; 3 Suppl 66-71.
  • 13 Bostedt H, Maier G, Herfen K, Hospes R. Klinische Erhebungen bei Sauen mit puerperaler Septikämie und Toxämie. Tierärztl Prax 1998; 26 G 332-338.
  • 14 Brummelmann BB. Uterine bacterial flora of sows and the relationship with fertility. Proc 6th IPVS Congress Denmark Copenhagen: 1980: 58 (Abstract).
  • 15 Busch M, Thoma R, Schiller I, Corboz L, Pospischil A. Occurrence of chlamydiae in the genital tracts of sows at slaughter and their possible significance for reproductive failure. J Vet Med B 2000; 47: 471-480.
  • 16 Dänicke S, Döll S, Goyarts T, Velenta H, Ueberschär K-H, Flachowsky G. Zur Beurteilung des Vorkommens der Fusarium-Toxine Deoxynivalenol (DON) und Zearalenon (ZON) sowie ihrer Metaboliten in physiologischen Substraten des Schweins. Tierärztl Prax 2008; 36 G 35-47.
  • 17 Dalin AM, Gidlund K, Eliasson-Selling L. Post-mortem examination of genital organs from sows with reproductive disturbances in a sow-pool. Acta Vet Scand 1997; 38: 253-262.
  • 18 Dalin AM, Kaeoket K, Persson E. Immune cell infiltration of normal and impaired sow endometrium. Anim Reprod Sci 2004; 82–83: 401-413.
  • 19 D’Allaire S, Stein TE, Leman AD. Culling patterns in selected Minnesota swine herds. Can J Vet Res 1987; 51: 502-512.
  • 20 Dee SA. Porcine urogenital disease. Vet Clin North Am Food Anim Pract 2008; 8: 641-660.
  • 21 DeGraves FJ, Gao D, Hehnen H-R, Schlapp T, Kaltenboeck B. Quantitative detection of Chlamydia psittaci and C. pecorum by high-sensitivity real-time PCR reveals high prevalenve of vaginal infection in cattle. J Clin Microbiol 2003; 41: 1726-1729.
  • 22 DeGraves FJ, Kim TY, Jee JB, Schlapp T, Hehnen H-R, Kaltenboeck B. Reinfection with Chlamydophila abortus by uterine and indirect cohort routes reduces fertility in cattle preexposed to Chlamydophila. Infect Immun 2004; 72: 2538-2545.
  • 23 De Winter PJJ, Verdonck M, de Kruif A, Devriese LA, Haesebrouck F. Bacterial endometritis and vaginal discharge in the sow: prevalence of different bacterial species and experimental reproduction of the syndrome. Anim Reprod Sci 1995; 37: 325-335.
  • 24 De Winter PJJ, Verdonck M, de Kruif A, Coryn M, Deluyker HA, Devriese LA, Haesebrouck F. The relationship between the blood progesterone concentration at early metoestrus and uterine infection in the sow. Anim Reprod Sci 1996; 41: 51-59.
  • 25 Ebbert W, Bostedt H. Cystic degeneration in porcine ovaries – first communication: morphology of cystic ovaries, interpretation of the results. Reprod Dom Anim 1993; 28: 441-450.
  • 26 Falceto MV, Cruz JI, Gil L. et al. Pathological findings in the genital tract in the sow. Proc 9th ICAR, Madrid, Spanien, 1980: 42-44.
  • 27 Földi J, Kulcsár M, Pécsi A, Huyghe B, de Sa C, Lohuis JACM, Cox P, Huszenicza Gy. Bacterial complications of postpartum uterine involution in cattle. Anim Reprod Sci 2006; 96: 265-281.
  • 28 Glock XTP, Bilkei G. The effect of postparturient urogenital disease on the lifetime reproductive performance of sows. Can Vet J 2005; 46: 1103-1107.
  • 29 Grobbel M, Lübke-Becker A, Alesík E, Schwarz S, Wallmann J, Werckenthin C, Wieler LH. Antimicrobial susceptibility of Escherichia coli from swine, horses, dogs and cats as determined in the BfT-GermVet monitoring program 2004–2006. Berl Münch Tierärztl Wschr 2007; 120: 391-401.
  • 30 Grobbel M, Lübke-Becker A, Alesík E, Schwarz S, Wallmann J, Werckenthin C, Wieler LH. Antimicrobial susceptibility of Klebsiella spp. and Proteus spp. from various organ systems of horses, dogs and cats as determined in the BfT-GermVet monitoring program 2004–2006. Berl Münch Tierärztl Wschr 2007; 120: 402-411.
  • 31 Halgaard C. Epidemiologic factors in puerperal diseases of sow. Nord Vet Med 1983; 35 (Suppl. 04) 161-174.
  • 32 Heinonen M, Leppavuori A, Pyorala S. Evaluation of reproductive failure of female pigs based on slaughterhouse material and herd record survey. Anim Reprod Sci 1998; 52: 235-244.
  • 33 Heinritzi K, Hagn J. Untersuchungen zur Wirksamkeit und Verträglichkeit des neu entwickelten Cephalosporins Cefquinom bei an puerperaler Septikämie und Toxämie erkrankten Sauen. Tierärztl Prax 1999; 27 G 114-121.
  • 34 Hoffmann G. Occurrence of chlamydiae in porcine oviducts and uteri and their potential impact on infertility. PhD dissertation. Faculty of Veterinary Medicine, University of Leipzig Leipzig: 2007
  • 35 Hörugel K, Schnurrbusch U, Fischer S. Mould fungus contamination of feedstuff – effects on sow fertility and litter size. Mh Vet Med 1991; 46: 175-180.
  • 36 Hoy S. The impact of puerperal diseases in sows on their fertility and health up to next farrowing. Animal Sci 2006; 82: 701-704.
  • 37 Hurtgen JP. Pathogenesis and treatment of endometritis in the mare: a review. Theriogenology 2006; 66: 560-566.
  • 38 Hussein AM, Newby TJ, Bourne FJ. Immunohistochemical studies of the local immune system in the reproductive tract of the sow. J Reprod Immun 1983; 5: 1-15.
  • 39 Jana B, Kucharski J, Ziecik AJ. Effect of intrauterine infusion of Escherichia coli on hormonal patterns in gilts during the oestrous cycle. Reprod Nutr Dev 2004; 44: 37-48.
  • 40 Jana B, Kucharski J, Dzienis A, Deptula K. Changes in prostaglandin production and ovarian function in gilts during endometritis induced by Escherichia coli infection. Anim Reprod Sci 2007; 97: 137-150.
  • 41 Jee JB, DeGraves FJ, Kim TY, Kaltenboeck B. High prevalence of natural Chlamydophila species infection in calves. J Clin Microbiol 2004; 42: 5664-5672.
  • 42 Jiwakanon J, Persson E, Kaeoket K, Dalin AM. The sow endosalpinx at different stages of the oestrous cycle and at anoestrus: studies on morphological changes and infiltration by cells of the immune system. Reprod Domest Anim 2005; 40: 28-39.
  • 43 Kaeoket K, Persson E, Dalin AM. The sow endometrium at different stages of the oestrous cycle: studies on morphological changes and infiltration by cells of the immune system. Anim Reprod Sci 2001; 65: 95-114. Corrigendum M&M: Anim Reprod Sci 2002: 73; 89-107.
  • 44 Kaeoket K, Persson E, Dalin AM. Influence of pre-ovulatory insemination and early pregnancy on the infiltration by cells of the immune system in the sow endometrium. Anim Reprod Sci 2003; 75: 55-71.
  • 45 Kaeoket K, Persson E, Dalin AM. Influence of post-ovulatory insemination on sperm distribution, pregnancy and the infiltration by cells of the immune system, and the distribution of CD2, CD4, CD8 and MHC class II expressing cells in the sow endometrium. J Vet Med A Physiol Pathol Clin Med 2003; 50: 169-178.
  • 46 Kaeoket K, Tantasuparuk W, Kunavongkrit A. The effect of post-ovulatory insemination on the subsequent embryonic loss, oestrous cycle length and vaginal discharge in sows. Reprod Domest Anim 2005; 40: 492-494.
  • 47 Karlberg K, Rein KA, Nordstoga K. Histological and bacteriological examination of uterus from the repeat breeder gilt and sow. Nord Vet Med 1981; 33: 359-365.
  • 48 Kauffold J, Rautenberg T, Hoffmann G, Beynon N, Schellenberg I, Sobiraj A. A field study into the appropriateness of transcutaneous ultrasonography in the diagnoses of uterine disorders in reproductively failed pigs. Theriogenology 2005; 64: 1546-1558.
  • 49 Kauffold J, Melzer F, Henning K, Schulze K, Leiding C, Sachse K. Prevalence of chlamydiae in boars and semen used for artificial insemination. Theriogenology 2006; 65: 1750-1758.
  • 50 Kauffold J, Melzer M, Berndt A, Hoffmann G, Hotzel H, Sachse K. Chlamydiae in oviducts and uteri of the repeat breeder pig. Theriogenology 2006; 66: 1816-1823.
  • 51 Kauffold J, Hoeruegel K, Beynon N, Sobiraj A. Ultrasonographische Charakterisierung von Uteri und Ovarien fertiler Altsauen nach dem Absetzen und in der darauffolgenden Brunst. Tierärztl Prax 2006; 34 G 35-39.
  • 52 Kauffold J, Althouse GC. An update on the use of B-mode ultrasonography in female pig reproduction. Theriogenology 2007; 67: 901-11.
  • 53 Kauffold J. Update zum Vorkommen von Chlamydien beim Schwein. Tierärztliche Praxis (G) 2008; 36: 57-63.
  • 54 Klein C, Lottner S, Huchzermeyer S, Weiss R, Wehrend A. Untersuchungen zur mikrobiellen Barrierefunktion des Hymenalrings und der Zervix bei der Stute. Tierärztl Prax 2008 (eingereicht).
  • 55 Knox RV, Althouse GC. Visualizing the reproductive tract of the female pig using real-time ultrasonography. J Swine Health Prod 1999; 7: 207-215.
  • 56 Koketsu Y, Dial GD, King VL. Returns to service after mating and removal of sows for reproductive reasons from commercial swine farms. Theriogenology 1997; 47: 1347-1363.
  • 57 Langendijk P, Bouwman EG, Soede NM, Taverne MA, Kemp B. Myometrial activity around estrus in sows: spontaneous activity and effects of estrogens, cloprostenol, seminal plasma and clenbuterol. Theriogenology 2002; 57: 1563-1577.
  • 58 Leiser R, Zimmermann W, Sidler X, Christen A. The morphology of endometrium and ovaries in normally cycling sows. Tierärztl Prax 1988; 16: 261-280.
  • 59 Lucia T, Dial GD, Marsh WE. Patterns of female removal. I. Longevity and lifetime performance for females with different reasons for removal. Proc 14th IPVS Congress Bologna, Italy: 1996: 540 (Abstract).
  • 60 Maes D, Verdonck M, De Kruif A. Vaginal microecology and vulval discharge in swine. Proc Old Herborn University Seminar Herborn, Germany: 1998: 39-48.
  • 61 Martinat-Botté F, Renaud G, Madec F, Costiou P, Terqui M. Echographie & reproduction chez la truie. Paris: INRA Editions, Hoechst Roussel Vet,; 1998
  • 62 Martinez E, Vazquez JM, Roca J, Ruiz S. Use of real-time ultrasonic scanning for the detection of reproductive failure in pig herds. Anim Reprod Sci 1992; 29: 53-59.
  • 63 Meredith M. Non-specific bacterial infections of the genital tract in female pigs. Pig Vet J 1991; 27: 101-121.
  • 64 Murihead MR. Epidemiology and control of vaginal discharges in the sow after service. Vet Rec 1986; 6: 233-235.
  • 65 Oravainen J, Heinonen M, Seppä-Lassila L, Orro T, Tast A, Virolainen J, Peltoniemi O. Factors affecting fertility in loosely housed sows and gilts: vulvar discharge syndrome, environment and acute-phase proteins. Reprod Domest Anim 2006; 41: 549-554.
  • 66 Oravainen J, Heinonen M, Tast A, Virolainen JV, Peltoniemi OA. Vulvar discharge syndrome in loosely housed Finnish pigs: prevalence and evaluation of vaginoscopy, bacteriology and cytology. Reprod Domest Anim 2008; 43: 42-47.
  • 67 Payne BJ, Clark S, Maddox C, Ness A. Achromobacter xylosoxidans: Causative agent of reproductive failure in artificially-inseminated sows and gilts. J Swine Health Prod. 2008 (in press).
  • 68 Plonait H. Lehrbuch der Schweinekrankheiten. Berlin, Hamburg: Parey; 1988: 294-295.
  • 69 Schnurrbusch U, Erices J. Histomorphological changes in the uterus of gilts during the first 3 sexual cycles. Arch Exp Veterinarmed 1979; 33: 527-546.
  • 70 Schnurrbusch U, Erices J, Elze K. Einsatz histologischer Methoden zur Beurteilung der Funktion von Ovarien und Uterus beim Schwein. Mh Vet Med 1985; 40: 422-426.
  • 71 Schnurrbusch U. Mykotoxine – eine zunehmende Gefahr für die Gesundheit der Tierbestände?. Schriftenreihe der Sächsischen Landesanstalt für Landwirtschaft 2004; 1: 127-135.
  • 72 Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO. Defining postpartum uterine disease in cattle. Theriogenology 2006; 65: 1516-1530.
  • 73 Tiemann U, Dänicke S. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review. Food Addit Contam 2007; 24: 306-314.
  • 74 Vandeplassche M, Geurden M, Van den Wijngaert M, Snoeck G, De Vos A. Puerperale Septikämie und Toxämie des Schweines. Dtsch Tierärztl Wschr 1960; 67: 375-377.
  • 75 Vanrompay D, Hoang TQ, De Vos L, Verminnen K, Harkinezhad T, Chiers K, Morré SA, Cox E. Specific-pathogen-free pigs as an animal model for studying Chlamydia trachomatis genital infection. Infect Immun 2005; 73: 8317-8321.
  • 76 Waldmann K-H. Therapeutische Maßnahmen bei MMA – schulmedizinische Therapie. Proc Bpt-Kongress Leipzig, Deutschland: 1999: 152-153.
  • 77 Waller CM, Bilkei G, Cameron RDA. Effect of periparturient diseases accompanied by excessive vulval discharge and weaning to mating interval on sow reproductive performance. Aus Vet J 2002; 80: 545-549.
  • 78 Wegener HC, Skov-Jensen EW. A longitudinal study of Staphylococcus hyicus colonization of vagina of gilts and transmission to piglets. Epidemiol Infect 1992; 109: 433-444.
  • 79 Weitze KF, Rath D. Konservierung von Schweinesperma. Ein Zwischenbericht über die laufenden Untersuchungen. SUS 1987; 35: 391-397.
  • 80 Wulster-Radcliffe MC, Seals RC, Lewis GS. Progesterone increases susceptibility of gilts to uterine infections after intrauterine inoculation with infectious bacteria. J Anim Sci 2003; 81: 1242-1252.
  • 81 Zimmermann J, Benfield DA, Murtaugh MP, Osorio F, Stevenson GW, Torremorell M. Porcine Reproductive and Respiratory Syndrome Virus (Porcine Arterivirus). In: Diseases of Swine, 9th ed. Straw BE, D’Allaire Mengeling WL, Taylor DJ. eds. Ames, Iowa, USA: Blackwell; 2006: 387-417.