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Tierarztl Prax Ausg K Kleintiere Heimtiere 2008; 36(06): 393-398
DOI: 10.1055/s-0038-1622700
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Schattauer GmbH

Zur Anwendung von Butorphanol in der Veterinärmedizin

Eine ÜbersichtUse of butorphanol in veterinary practice
S. B. R. Kästner
1   Klinik für kleine Haustiere (Direktor: Prof. Dr. I. Nolte) der Stiftung Tierärztliche Hochschule Hannover
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Further Information

Publication History

Eingegangen:12 February 2008

akzeptiert:21 May 2008

Publication Date:
04 January 2018 (online)

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Zusammenfassung:

Butorphanol wird international seit mehreren Jahrzehnten in der Humanund Veterinärmedizin als Analgetikum, zur sedativ-analgetischen Anästhesieprämedikation und als Antitussivum eingesetzt. Das Ziel der vorliegenden Arbeit ist, anhand einer Literaturübersicht die pharmakologischen Eigenschaften, klinischen Wirkungen und Einsatzgebiete von Butorphanol in der Veterinärmedizin darzustellen. In den Datenbanken Pubmed und CAB International erfolgte eine Literaturrecherche mit dem Suchbegriff „butorphanol*“. Insgesamt wurden 84 Literaturstellen in die Übersicht einbezogen. Butorphanol ist ein vollsynthetischer Morphinabkömmling. In Deutschland unterliegt der Wirkstoff derzeit nicht den betäubungsmittelrechtlichen Bestimmungen. Seine Hauptwirkungen entfaltet Butorphanol als Agonist an den κ-Opiatrezeptoren. Butorphanol vermittelt bei Pferd, Hund und Katze eine effektive viszerale Analgesie mit einer dosisabhängigen kurzen bis mittleren Wirkungsdauer. Im Bereich der somatischen Analgesie zeigte es bei diesen Spezies eine geringe Effektivität. Als Hauptindikationen für die Anwendung von Butorphanol bei Pferd und Kleintier müssen Sedation, Anästhesie Prämedikation und perioperative Analgesie im Zusammenhang mit abdominalen chirurgischen Eingriffen sowie die Therapie des Kolikschmerzes beim Pferd betrachtet werden.

Summary

Butorphanol has been used for decades as analgesic, premedication and antitussive agent in human and veterinary medicine. The aim of this review was to summarize the pharmacologic properties, clinical effects and utilities of butorphanol in veterinary medicine. The databases “Pubmed” and CAB International were searched for “butorphanol*”. Overall 84 articles were included in the review. Butorphanol is a synthetic morphine derivative. It is currently not a controlled drug in Germany. Its main effects are mediated via agonistic effects at the κ-opioid receptors. Butorphanol produces an effective visceral analgesia of short to moderate duration in horses, dogs and cats. For the treatment of somatic pain it has shown low effectiveness. The main indication for the use of butophanol is sedation, anaesthetic premedication and perioperative analgesia for abdominal surgery in small animals and horses and treatment of colic pain in horses.

Schlüsselwörter

Butorphanol - Analgesie - Sedation - Pferd - Hund - Katze

Key words

Butorphanol - analgesia - sedation - horse - dog - cat
 

  • Literatur

  • 1 Al-Gizawiy M, Rudé EP. Comparison of preoperative carprofen and postoperative butorphanol as postsurgical analgesics in cats undergoing ovariohysterectomy. Vet Anaesth Analg 2004; 31: 164-174.
    CrossrefPubMedGoogle Scholar
  • 2 Ansah O, Vainio O, Hellsten C, Raekallio M. Postoperative pain control in cats: clinical trials with medetomidine and butorphanol. Vet Surg 2002; 31: 99-103.
    CrossrefPubMedGoogle Scholar
  • 3 Borer L, Peel J, Seewald W, Schawalder P, Spreng D. Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. Am J Vet Res 2003; 64: 1429-1437.
    CrossrefPubMedGoogle Scholar
  • 4 Brodbelt D, Taylor P. Comparison of two combinations of sedatives before anaesthetising pigs with halothane and nitrous oxide. Vet Rec 1999; 145: 283-287.
    CrossrefPubMedGoogle Scholar
  • 5 Browning A, Collins J. Sedation of horse with romifidine and butorphanol. Vet Rec 1994; 134: 90-91.
    CrossrefPubMedGoogle Scholar
  • 6 Brunson D, Majors L. Comparative analgesia of xylazine, xylazine/mor - phine, xylazine/butorphanol, and xylazine/nalbuphine in the horse, using dental dolorimetry. Am J Vet Res 1987; 48: 1087-1091.
    PubMedGoogle Scholar
  • 7 Butelman E, Winger G, Zernig G, Woods J. Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys. J Pharmacol Exp Therap 1995; 27: 845-853.
    PubMedGoogle Scholar
  • 8 Carroll G, Boothe D, Hartsfield S, Martinez E, Spann A, Hernandez A. Pharmacokinetics and pharmacodynamics of butorphanol in llamas after intra - venous and intramuscular administration. J Am Vet Med Assoc 2001; 219: 1263-1267.
    CrossrefPubMedGoogle Scholar
  • 9 Caulkett N, Read M, Fowler D, Waldner C. A comparison of the analgesic effects of butorphanol with those of meloxicam after elective ovariohysterectomy in dogs. Can Vet J 2003; 44: 565-570.
    PubMedGoogle Scholar
  • 10 Cavanagh R, Gylys J, Bierwagen M. Antitussive properties of butorphanol. Arch Int Pharmacodyn Ther 1976; 220: 258-268.
    PubMedGoogle Scholar
  • 11 Chang K, Cuatrecasas P. Heterogeneity and properties of opiate receptors. Fed Proc 1981; 40: 2729-2734.
    PubMedGoogle Scholar
  • 12 Chang K, Hazum E, Cuatrecasas P. Novel opiate binding sites selective for benzomorphan drugs. Proc Natl Acad Sci 1981; 78: 4141-4145.
    CrossrefPubMedGoogle Scholar
  • 13 Christie G, Strom P, Rourke J. Butorphanol tartrate: a new antitussive agent for use in dogs. Vet Med Small Anim Clin 1980; 75: 1559-1562.
    PubMedGoogle Scholar
  • 14 Clarke K, Patson B. Combined use of detomidine with opiates in the horse. Equine Vet J 1988; 20: 331-334.
    CrossrefPubMedGoogle Scholar
  • 15 Commiskey S, Fan L, Ho I, Rockhold R. Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci 2005; 98: 109-116.
    CrossrefPubMedGoogle Scholar
  • 16 Corletto F, Raisis A, Brearley J. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Vet Anaesth Analg 2005; 32: 16-22.
    PubMedGoogle Scholar
  • 17 Court M, Dodman N, Levine H, Richey M, Lee J, Hustead D. Pharmacokinetics and milk residues of butorphanol in dairy cows after single intravenous administration. J Vet Pharmacol Therap 1992; 15: 28-35.
    CrossrefPubMedGoogle Scholar
  • 18 Davis G, Rudy A, Archer S, Wermeling D. Bioavailability of intranasal butorphanol administered from a single-dose sprayer. Am J Health Syst Pharm 2005; 62: 48-53.
    PubMedGoogle Scholar
  • 19 Dodam J, Cohn L, Durham H, Szladovits B. Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs. Vet Anaesth Analg 2004; 31: 129-132.
    CrossrefPubMedGoogle Scholar
  • 20 Doherty T, Geiser D, Rohrbach B. Effect of acepromazine and butorphanol on halothane minimum alveolar concentration in ponies. Equine Vet J 1997; 29: 374-376.
    CrossrefPubMedGoogle Scholar
  • 21 Doherty T, Rohrbach B, Geiser D. Effect of acepromazine and butorphanol on isoflurane minimum alveolar concentration in goats. J Vet Pharmacol Therap 2002; 25: 65-67.
    CrossrefPubMedGoogle Scholar
  • 22 Fan L, Tanaka S, Tien L, Ma T, Rockhold R, Ho I. Withdrawal from dependence upon butorphanol uniquely increases kappa(01)-opioid receptor binding in the rat brain. Brain Res Bull 2002; 58: 149-160.
    CrossrefPubMedGoogle Scholar
  • 23 Fox S, Mellor D, Stafford K, Lowoko C, Hodge H. The effects of ovariohysterectomy plus different combinations of halothane anaesthesia and butor - phanol analgesia on behaviour in the bitch. Res Vet Sci 2000; 68: 265-274.
    CrossrefPubMedGoogle Scholar
  • 24 Garcia-Pereira FL, Greene SA, Keegan RD, McEwen MM, Tibary A. Effects of intravenous butorphanol on cardiopulmonary function in isoflurane-anesthetized alpacas. Vet Anaesth Analg 2007; 34: 269-274.
    CrossrefPubMedGoogle Scholar
  • 25 Gaver R, Vasiljev M, Wong H, Monkovic I, Swigor J, Harken DV, Smyth R. Disposition of parenteral butorphanol in man. Drug Metab Dispos 1980; 8: 230-235.
    PubMedGoogle Scholar
  • 26 Gross ME, Smith JA, Tranquilli WJ. Cardiorespiratory effects of combined midazolam and butorphanol in isoflurane-anesthetized cats. Vet Surg 1993; 22: 159-162.
    CrossrefPubMedGoogle Scholar
  • 27 Guard C, Schwark W, Kelton D, Dobson A. Effects of metoclopramide, clenbuterol and butorphanol on ruminoreticular motility of calves. Cornell Vet 1988; 78: 89-98.
    PubMedGoogle Scholar
  • 28 Hainisch E. Sedation by continous intravenous detomidine drip for standing surgical procedures. Equine Vet Educ 2001; 13: 51-52.
    PubMedGoogle Scholar
  • 29 Hall T, Duke T, Townsend H, Caulkett N, Cantwell S. The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in cats. Can Vet J 1999; 40: 867-870.
    PubMedGoogle Scholar
  • 30 Hofmeister H, Mackey E, Trim C. Effect of butorphanol administration on cardiovascular parameters in isoflurane-anesthetized horses – a retrospective clinical evaluation. Vet Anaesth Analg 2008; 35: 38-44.
    CrossrefPubMedGoogle Scholar
  • 31 Horan P, Ho I. Comparative pharmacological and biochemical studies be - tween butorphanol and morphine. Pharmacol Biochem Behav 1989; 34: 847-854.
    CrossrefPubMedGoogle Scholar
  • 32 Houghton K, Rech R, Sawyer D, Durham R, Adams T, Langham M, Striler E. Dose-response of intravenous butorphanol to increase visceral nociceptive threshold in dogs. Proc Soc Exp Biol Med 1991; 197: 290-296.
    CrossrefPubMedGoogle Scholar
  • 33 Ilkiw J, Pascoe P, Tripp L. Effects of morphine, butorphanol, buprenorphine, and U50488H on the minimum alveolar concentration of isoflurane in cats. Am J Vet Res 2002; 63: 1198-1202.
    CrossrefPubMedGoogle Scholar
  • 34 Inoue T, Ko J, Mandsager R, Payton M, Galloway D, Lange D. Efficacy and safety of preoperative etodolac and butorphanol administration in dogs undergoing ovariohysterectomy. J Am Anim Hosp Assoc 2006; 42: 178-188.
    CrossrefPubMedGoogle Scholar
  • 35 Jaw S, Hoskins B, Ho I. Opioid antagonists and butorphanol dependence. Pharmacol Biochem Behav 1993; 44: 497-500.
    CrossrefPubMedGoogle Scholar
  • 36 Jaw S, Makimura M, Oh K, Hoskins B, Ho I. Involvement of kappa-opioid receptors in opioid dependence/withdrawal: studies using butorphanol. Eur J Pharmacol 1994; 257: 153-160.
    CrossrefPubMedGoogle Scholar
  • 37 Joubert K, Briggs P, Gottschalk R. The sedative and analgesic effects of detomidine-butorphanol and detomidine alone in donkeys. J South Afr Vet Assoc 1999; 70: 112-118.
    PubMedGoogle Scholar
  • 38 Kallos T, Caruso F. Respiratory effects of butorphanol and pethidine. Anaesthesia 1979; 34: 633-637.
    CrossrefPubMedGoogle Scholar
  • 39 Kalpravidh M, Lumb W, Wright M, Heath R. Analgesic effects of butorphanol in horses: dose-response studies. Am J Vet Res 1984; 45: 211-216.
    PubMedGoogle Scholar
  • 40 Kalpravidh M, Lumb W, Wright M, Heath R. Effects of butorphanol, flunixin, levorphanol, morphine, and xylazine in ponies. Am J Vet Res 1984; 45: 217-223.
    PubMedGoogle Scholar
  • 41 Ko J, Heaton-Jones T, Nicklin C. Evaluation of the sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, medetomidineketamine, and medetomidine-butorphanol-ketamine in ferrets. J Am Anim Hosp Assoc 1997; 33: 438-448.
    CrossrefPubMedGoogle Scholar
  • 42 Ko J, Lange D, Mandsager R, Payton M, Bowen C, Kamata A, Kuo W. Effects of butorphanol and carprofen on the minimal alveolar concentration of isoflurane in dogs. J Am Vet Med Assoc 2000; 217: 1025-1028.
    CrossrefPubMedGoogle Scholar
  • 43 Ko JCH, Bailey JE, Pablo LS Heaton, Jones TG. Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. Am J Vet Res 1996; 57: 535-540.
    PubMedGoogle Scholar
  • 44 Ko JCH, Fox SM, Mandsager RE. Sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, and medetomidine-ketamine in dogs. J Am Vet Med Assoc 2000; 216: 1578-1583.
    CrossrefPubMedGoogle Scholar
  • 45 Kohn C, Muir W. Selected aspects of the clinical pharmacology of visceral analgesics and gut motility modifying drugs in the horse. J Vet Intern Med 1988; 2: 85-91.
    CrossrefPubMedGoogle Scholar
  • 46 Lascelles B, Robertson S. Antinociceptive effects of hydromorphone, butorphanol, or the combination in cats. J Vet Intern Med 2004; 18: 190-195.
    CrossrefPubMedGoogle Scholar
  • 47 Lascelles BDX, Robertson SA. Use of thermal threshold response to evalu - ate the antinociceptive effects of butorphanol in cats. Am J Vet Res 2004; 65: 1085-1089.
    CrossrefPubMedGoogle Scholar
  • 48 Leander J. A kappa opioid effect: increased urination in the rat. J Pharmacol Exp Therap 1983; 224: 89-94.
    PubMedGoogle Scholar
  • 49 Leander J, Hart J, Zerbe R. Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels. J Pharmacol Exp Therap 1987; 242: 33-39.
    PubMedGoogle Scholar
  • 50 Lemke K, Tranquilli W, Thurmon J, Benson G, Olson W. Ability of flumazenil, butorphanol, and naloxone to reverse the anesthetic effects of oxymorphone- diazepam in dogs. J Am Vet Med Assoc 1996; 209: 776-779.
    PubMedGoogle Scholar
  • 51 Leppänen M, McKusick B, Granholm M, Westerholm F, Tulamo R, Short C. Clinical efficacy and safety of dexmedetomidine and buprenorphine, butorphanol or diazepam for canine hip radiography. J Small Anim Pract 2006; 47: 663-669.
    CrossrefPubMedGoogle Scholar
  • 52 Lin H, Riddell M. Preliminary study of the effects of xylazine or detomidine with or without butorphanol for standing sedation in dairy cattle. Vet Ther 2003; 4: 285-291.
    PubMedGoogle Scholar
  • 53 Matthews N, Lindsay S. Effect of low-dose butorphanol on halothane minimum alveolar concentration in ponies. Equine Vet J 1990; 22: 325-327.
    CrossrefPubMedGoogle Scholar
  • 54 McCrackin M, Harvey R, Sackman J, McLean R, Paddleford R. Butorphanol tartrate for partial reversal of oxymorphone-induced postoperative respiratory depression in the dog. Vet Surg 1994; 23: 67-74.
    CrossrefPubMedGoogle Scholar
  • 55 Merritt A, Campbell-Thompson M, Lowrey S. Effect of butorphanol on equine antroduodenal motility. Equine Vet J Suppl 1989; 21-23.
    PubMedGoogle Scholar
  • 56 Natalini C, Robinson E. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am J Vet Res 2000; 61: 1579-1586.
    CrossrefPubMedGoogle Scholar
  • 57 Paronis C, Woods J. Ventilation in morphine-maintained rhesus monkeys. II: Tolerance to the antinociceptive but not the ventilatory effects of morphine. J Pharmacol Exp Therap 1997; 282: 355-362.
    PubMedGoogle Scholar
  • 58 Pfeffer M, Smyth R, Pittman K, Nardella P. Pharmacokinetics of subcutaneous and intramuscular butorphanol in dogs. J Pharm Sci 1980; 69: 801-803.
    CrossrefPubMedGoogle Scholar
  • 59 Portnoy L, Hustead D. Pharmacokinetics of butorphanol tartrate in rabbits. Am J Vet Res 1992; 53: 541-543.
    PubMedGoogle Scholar
  • 60 Quandt J, Raffe M, Robinson E. Butorphanol does not reduce the minimum alveolar concentration of halothane in dogs. Vet Surg 1994; 3: 156-159.
    PubMedGoogle Scholar
  • 61 Roberts M, Argenzio A. Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal transit in ponies. Equine Vet J 1986; 18: 256-260.
    CrossrefPubMedGoogle Scholar
  • 62 Robertson J, Muir W, Sams R. Cardiopulmonary effects of butorphanol tartrate in horses. Am J Vet Res 1981; 42: 41-44.
    PubMedGoogle Scholar
  • 63 Robertson SA, Taylor PM, Lascelles BDX, Dixon MJ. Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine. Vet Rec 2003; 153: 462-465.
    CrossrefPubMedGoogle Scholar
  • 64 Roebel L, Cavanagh R, Buyniski J. Comparative gastrointestinal and biliary tract effects of morphine and butorphanol (Stadol). J Med 1979; 10: 225-238.
    PubMedGoogle Scholar
  • 65 Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T, Tamura H, Takeuchi A. Enhancing effect of butorphanol on medetomidine-induced sedation in pigs. J Vet Med Sci 1992; 54: 1183-1185.
    CrossrefPubMedGoogle Scholar
  • 66 Sawyer D, Rech R, Durham R, Adams T, Richter M, Striler E. Dose re - sponse to butorphanol administered subcutaneously to increase visceral nociceptive threshold in dogs. Am J Vet Res 1991; 52: 1826-1830.
    PubMedGoogle Scholar
  • 67 Schatzman U, Armbruster S, Stucki F, Busato A, Kohler I. Analgesic effect of butorphanol and levomethadone in detomidine sedated horses. J Vet Med A Physiol Pathol Clin Med 2001; 48: 337-342.
    CrossrefPubMedGoogle Scholar
  • 68 Scrivani PV, Bednarski RM, Myer CW. Effects of acepromazine and butor - phanol on positive-contrast upper gastrointestinal tract examination in dogs. Am J Vet Res 1998; 59: 1227-1233.
    PubMedGoogle Scholar
  • 69 Sellon D, Monroe V, Roberts M, Papich M. Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or con - tinuous intravenous infusion in horses. Am J Vet Res 2001; 62: 183-189.
    CrossrefPubMedGoogle Scholar
  • 70 Sellon D, Roberts M, Blikslager A, Ulibarri C, Papich M. Effects of con - tinuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy. J Vet Intern Med 2004; 18: 555-563.
    CrossrefPubMedGoogle Scholar
  • 71 Selmi A, Mendes G, Lins B, Figueiredo J, Barbudo-Selmi G. Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine- butorphanol, and dexmedetomidine-ketamine in cats. J Am Vet Med Assoc 2003; 222: 37-41.
    CrossrefPubMedGoogle Scholar
  • 72 Skarda R, Muir W. Comparison of electroacupuncture and butorphanol on respiratory and cardiovascular effects and rectal pain threshold after con - trolled rectal distention in mares. Am J Vet Res 2003; 64: 137-144.
    CrossrefPubMedGoogle Scholar
  • 73 Smith AA, Posner LP, Goldstein RE, Ludders JW, Erb HN, Simpson KW, Gleed RD. Evaluation of the effects of premedication on gastroduodeno - scopy in cats. J AmVet Med Assoc 2004; 225: 540-544.
    PubMedGoogle Scholar
  • 74 Sojka S, Adams S, Lamar C, Eller L. Effect of butorphanol, pentazocine, meperidine, or metoclopramide on intestinal motility in female ponies. Am J Vet Res 1988; 49: 527-529.
    PubMedGoogle Scholar
  • 75 Spadavecchia C, Arendt-Nielsen L, Spadavecchia L, Mosing M, Auer U, van den Hoven R. Effects of butorphanol on the withdrawal reflex using threshold, suprathreshold and repeated subthreshold electrical stimuli in conscious horses. Vet Anaesth Analg 2007; 34: 48-58.
    CrossrefPubMedGoogle Scholar
  • 76 Talbert R, Peters J, Sorrells S, Simmons R. Respiratory effects of high-dose butorphanol. Acute Care 1988; 12: 47-56.
    PubMedGoogle Scholar
  • 77 Troncy E, Besner J, Charbonneau R, Cuvelliez S, Blais D. Pharmacokinetics of epidural butorphanol in isoflurane-anaesthetized dogs. J Vet Pharmacol Therap 1996; 19: 268-273.
    CrossrefPubMedGoogle Scholar
  • 78 Troncy E, Cuvelliez S, Blais D. Evaluation of analgesia and cardiorespiratory effects of epidurally administered butorphanol in isoflurane-anesthetized dogs. Am J Vet Res 1996; 57: 1478-1482.
    PubMedGoogle Scholar
  • 79 Turner P, Kerr C, Healy A, Taylor W. Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits. Am J Vet Res 2006; 67: 770-774.
    CrossrefPubMedGoogle Scholar
  • 80 Ugarte C, O’Flaherty K. The use of a medetomidine, butorphanol and atropine combination to enable, blood sampling in young pigs. N Z Vet J 2005; 53: 249-252.
    CrossrefPubMedGoogle Scholar
  • 81 Waterman A, Livingston A, Amin A. Analgesic activity and respiratory effects of butorphanol in sheep. Res Vet Sci 1991; 51: 19-23.
    CrossrefPubMedGoogle Scholar
  • 82 Westermann C, Laan T, Nieuwstadt Rv, Bull S, Fink-Gremmels J.. Effects of antitussive agents administered before bronchoalveolar lavage in horses. Am J Vet Res 2005; 66: 1420-1424.
    CrossrefPubMedGoogle Scholar
  • 83 Woods J, Gmerek D. Substitution and primary dependence studies in animals. Drug Alcohol Depend 1985; 14: 233-247.
    CrossrefPubMedGoogle Scholar
  • 84 Yamashita K, Okano Y, Yamashita M, Umar M, Kushiro T, Muir W. Effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration of sevoflurane in dogs. J Vet Med Sci 2008; 70: 29-35.
    CrossrefPubMedGoogle Scholar