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Nuklearmedizin 1980; 19(01): 25-28
DOI: 10.1055/s-0037-1620927
Originalarbeiten - Original Articles
Schattauer GmbH

The Relationship of 67Ga Uptake to Citrate Dose, Compared with 67Ga-Chloride and 67Ga-Transferrin in Rodent Tissues and Tumours

Die Beziehung von 67Ga-Aufnahme und Zitratdosis verglichen mit 67Ga-Chlorid und 67Ga-Transferrin in Gewebe und Tumoren von Nagetieren
P. A. G. Hammersley
1   From the Radiopharmacology Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
,
Maureen A. Zivanovic
1   From the Radiopharmacology Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
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Publication History

Received: 20 September 1979

Publication Date:
09 January 2018 (online)

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The uptake of 67Ga-citrate in the tissues of the mouse and rat and in two mouse tumours, S180 and PC6, has been measured and shown to be independent of the citrate concentration of the injection dose. The tumour uptake and tissue distribution of 67Ga-chloride and 67Ga-transferrin were identical with those of the citrate complex. Whole-body retention data for h7Ga-citrate in the mouse for 14 days after injection are also presented.

Die Aufnahme von 67Ga-Zitrat in das Gewebe von Mäusen und Ratten und in zwei Mäusetumore, S180 und PC6, wurde gemessen und es zeigte sich, daß sie unabhängig von der Zitratkonzentration der Injektionsdosis war. Die Tumoraufnahme und die Gewebsverteilung von 67Ga-Chlorid und 67Ga-Transferrin waren identisch mit denen des Zitratkomplexes. Die Ganzkörper-Retentionswerte für 67Ga-Zitrat in der Maus, 14 Tage nach Injektion, werden ebenfalls vorgelegt.

 

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