The Relationship of 67Ga Uptake to Citrate Dose, Compared with ⁶⁷Ga-Chloride and ⁶⁷Ga-Transferrin in Rodent Tissues and Tumours

The uptake of ⁶⁷Ga-citrate in the tissues of the mouse and rat and in two mouse tumours, S180 and PC6, has been measured and shown to be independent of the citrate concentration of the injection dose. The tumour uptake and tissue distribution of ⁶⁷Ga-chloride and ⁶⁷Ga-transferrin were identical with those of the citrate complex. Whole-body retention data for h7Ga-citrate in the mouse for 14 days after injection are also presented.

Die Aufnahme von ⁶⁷Ga-Zitrat in das Gewebe von Mäusen und Ratten und in zwei Mäusetumore, S180 und PC6, wurde gemessen und es zeigte sich, daß sie unabhängig von der Zitratkonzentration der Injektionsdosis war. Die Tumoraufnahme und die Gewebsverteilung von ⁶⁷Ga-Chlorid und ⁶⁷Ga-Transferrin waren identisch mit denen des Zitratkomplexes. Die Ganzkörper-Retentionswerte für ⁶⁷Ga-Zitrat in der Maus, 14 Tage nach Injektion, werden ebenfalls vorgelegt.

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