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Nuklearmedizin 1978; 17(03): 95-98
DOI: 10.1055/s-0037-1620676
Originalarbeiten – Original Articles
Schattauer GmbH

Iron-Dextran Enhancement of 67Ga-Concentration in Abscess Relative to Normal Tissue

Relative Erhöhung der 67Ga-Konzentration in Abszessen durch Eisen-Dextran
S. M. Larson
1   From the Nuclear Medicine Section, Veterans Administration Hospital; the Department of Radiology and Division of Nuclear Medicine, University Hospital, Seattle, Wash, and the Nuclear Medicine Section, Veterans Administration Hospital, Portland, Ore., U.S.A.
,
D. Mahler
1   From the Nuclear Medicine Section, Veterans Administration Hospital; the Department of Radiology and Division of Nuclear Medicine, University Hospital, Seattle, Wash, and the Nuclear Medicine Section, Veterans Administration Hospital, Portland, Ore., U.S.A.
,
D.R. Allen
1   From the Nuclear Medicine Section, Veterans Administration Hospital; the Department of Radiology and Division of Nuclear Medicine, University Hospital, Seattle, Wash, and the Nuclear Medicine Section, Veterans Administration Hospital, Portland, Ore., U.S.A.
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Publikationsverlauf

Received: 21. April 1978

Publikationsdatum:
09. Januar 2018 (online)

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Iron-dextran (Imferon®) significantly increases the concentration of 67Ga in abscess relative to muscle, when given intravenously to abscess bearing rabbits 24 hr after intravenous, carrier-free 67Ga-citrate. This increase is achieved by accelerating the clearance of 67Ga from the blood.

Wenn Kaninchen Eisen-Dextran intravenös nach Gabe von trägerfreiem 67Ga-Zitrat verabreicht wird, erhöht es die 67Ga-Konzentration in Abszessen, bezogen auf Muskelgewebe, signifikant. Diese Erhöhung wird durch Beschleunigung der 67Ga-Clearance aus dem Blut bewirkt.

 

  • References

  • 1 Clauson J, Edelin C, Foh J. 67Ga-binding to human serum proteins and tumor components. Cancer Res 1974; 34: 1931.
    Suche in Google Scholar
  • 2 Gunasekera S. W, King L. J, Lavender P. J. The behavior of tracer gallium-67 towards serum proteins. Clin, chim. Acta 1972; 39: 401.
    CrossrefSuche in Google Scholar
  • 3 Hartman R. E, Hayes R. L. The binding of gallium by blood serum. Fed. Proc 1967; 26: 780.
    Suche in Google Scholar
  • 4 Hartman R. E, Hayes R. L. The binding of gallium by blood serum. J. Pharmacol, exp. Ther 1969; 168: 193.
    Suche in Google Scholar
  • 5 Hayes R. L, Edwards C. L. New applications of tumor localizing radiopharmaceuticals. In: Medical Radioisotope Scintigraphy. Vol. 2 IAEA; Vienna: 1973: 533-552.
    Suche in Google Scholar
  • 6 Herbert V. Drugs effective in iron deficiency and other hypochromic anemias. In: The Pharmacologic Basis of Therapeutics. Eds.: Goodman L. S, Gilman A.. McMillan Publishing Co.; New York, USA: 1975: 1317
    Suche in Google Scholar
  • 7 Oster Z. H, Larson S. M, Wagner Jr. H. N.. Possible enhancement of 67Ga-citrate imaging by iron-dextran. J. nucl. Med 1976; 17: 356.
    Suche in Google Scholar
  • 8 Yeung W. C, Larson S. M, Haines J. E. Simple method for zero extrapolation in plasma volume determination. J. nucl. Med 1975; 16: 1207.
    Suche in Google Scholar