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Arthritis und Rheuma 2008; 28(04): 219-222
DOI: 10.1055/s-0037-1620119
Diabetes und Rheuma
Schattauer GmbH

DISH-Syndrom und Diabetes mellitus

Diffuse idiopathic skeletal hyperostosis and diabetes mellitus
B. Linde
,
G. Hein
1   Friedrich-Schiller-Universität Jena, Klinik für Innere Medizin III (Direktor: Prof. Dr. Gunter Wolf), Rheumatologie/Osteologie (Leiter: Prof. Dr. Gert Hein)
› Author Affiliations
Further Information

Publication History

Publication Date:
24 December 2017 (online)

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Zusammenfassung

Das DISH-Syndrom (diffuse idiopathische Skeletthyperostose) ist eine mit dem Alter zunehmende nichtentzündlich bedingte Erkrankung aus dem rheumatischen Formenkreis, die sowohl zu einer Verknöcherung des perivertebralen Bindegewebes als auch der extravertebralen Sehnen- und Bandansätze führt. Die Ätiologie ist bislang unbekannt, es wird allerdings der Zusammenhang mit einer Hyperinsulinämie bei Diabetes mellitus Typ II vermutet. Klinisch ist eine schmerzhafte Bewegungseinschränkung der Wirbelsäule und der peripheren Gelenke auffällig. Radiologisch wird in den konventionellen Röntgenuntersuchungen die Diagnose durch Nachweis von Osteophyten und knöchernen Brückenbildungen entlang der Wirbelkörper gesichert. Therapeutisch steht neben der Analgesie eine intensive Physiotherapie im Vordergrund.

Summary

The DISH-syndrome (diffuse idiopathic skeletal hyperostosis) is a with age increasing non-inflammatory rheumatic disease. It’s characterized by ossification of the perivertebral connective tissue and of the peripheral entheses. The aetiology is so far unknown, however a correlation to hyperinsulinaemia at diabetes mellitus II is assumed. Clinically a painful movement restriction of the spinal column and peripheral joints is remarkable. The diagnosis is confirmed by the presence of osteophytes and bony-bridging along the vertebral bodies in conventional x-ray examinations. Therapeutic options are a sufficient analgesie and intensive physiotherapy.

Schlüsselwörter

DISH-Syndrom - Hyperostosen - Diabetes mellitus - Knochendichte

Keywords

DISH-Syndrome - hyperostosis - diabetes mellitus - bone mineral density
 

  • Literatur

  • 1 Boachie-Adjei O, Bullough PG. Incidence of ankylosing hyperostosis of the spine (Forestier’s Disease) at autopsy. Spine 1987; 12 (08) 739-743.
    CrossrefPubMedGoogle Scholar
  • 2 Daragon A, Mejjad O, Czernichow P. et al. Vertebral hyperostosis and diabetes mellitus: a case control study. Ann Rheum Diseases 1995; 54: 375-378.
    CrossrefPubMedGoogle Scholar
  • 3 Denko CW, Malemud JM. Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic disease. Semin Arthritis Rheum 2005; 35 (Suppl. 01) 24-34.
    PubMedGoogle Scholar
  • 4 Di Franco M, Mauceri MT, Sili-Scavalli A. et al. Study of peripheral bone mineral density in patients with diffuse idiopathic skeletal hyperostosis. Clin Rheumatol 2000; 19: 188-192.
    CrossrefPubMedGoogle Scholar
  • 5 El Miedany YM, Wassif G, El Baddini M. Diffuse idiopathic skeletal hyperostosis (DISH): Is it of vascular aetiology?. Clinical and Experimental Rheumatology 2000; 18: 193-200.
    PubMedGoogle Scholar
  • 6 Haykova Z, Streda A, Skrha F. Hyperostotic spondylosis and diabetes mellitus. Diabetologica 1965; 2: 123-126.
    Google Scholar
  • 7 Hein G. Glycation endproducts in osteoporosis – is there apathophysiologic importance?. Clin ChimActa 2006; 371 1–2 32-36.
    CrossrefPubMedGoogle Scholar
  • 8 Julkunen H, Knekt P, Aromaa A. Spondylosis deformans and diffuse idiopathic skeletal hyperostosis (DISH) in Finland. Scand J Rheumatol 1981; 10: 193
    CrossrefPubMedGoogle Scholar
  • 9 Julkunen H, Heinonen OP, Knekt P, Maatela J. The epidemiology of hyperostosis of the spine together with its symptoms and relates mortality in a general population. Scand J Rheumatol 1975; 4: 23
    CrossrefPubMedGoogle Scholar
  • 10 Kiss C, Szilágyi M, Paksy A, Poór G. Risk factors for diffuse idiopathic skeletal hyperostosis: a case- control study. Rheumatol 2000; 41: 27-30.
    Google Scholar
  • 11 Mader R, Dubenski N, Lavi I. Morbidity and mortality of hospitalized patients with diffuse idiopathic skeletal hyperostosis. Rheumatol Int 2005; 26: 132-136.
    CrossrefPubMedGoogle Scholar
  • 12 Mader R, Novofestovski I, Adawi M, Lavi I. Meta-bolic syndrome and cardiovascular risk in patients with diffuse idiopathic skeletal hyperostosis. Semin Arthritis Rheum 2008
    PubMedGoogle Scholar
  • 13 Mata S, Fortin P, Fitzcharles MA. et al. A controlled study of diffuse idiopathic skeletal hyperostosis: Clinical Features and Functional Status. Medicine 1997; 76: 104
    CrossrefPubMedGoogle Scholar
  • 14 Olivieri I, D’Angelo S, Cutro MS. et al. Diffuse idiopathic skeletal hyperostosis may give the typical postural abnormalities of advanced an kylosing spondy litis. Rheumatol 2007; 46: 1709-1711.
    CrossrefPubMedGoogle Scholar
  • 15 Sahin G, Polat G, Bagis S. et al. Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type I I diabetes mellitus. Womens Health 2002; 11 (09) 801-804.
    CrossrefPubMedGoogle Scholar
  • 16 Sarzi-Puttini P, Atzeni F. New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis). Curr Opin Rheumatol 2004; 16: 287-292.
    CrossrefPubMedGoogle Scholar
  • 17 Schlapbach P, Beyeler Ch, Gerber NJ. et al. Diffuse idiopathic skeletal hyperostosis (DISH) of the spine: a cause of pack Pain? A controlled Study. Brit J Rheumatol 1989; 28: 299-303.
    CrossrefPubMedGoogle Scholar
  • 18 Sencan D, Elden H, Nacitarhan V. et al. The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus. Rheumatol Int 2005; 25: 518-521.
    CrossrefPubMedGoogle Scholar
  • 19 Utsinger PD. Diffuse idiopathic skeletal hyperostosis. Clin Rheum Dis 1985; 11: 325
    PubMedGoogle Scholar