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Onkologische Welt 2016; 07(04): 167-170
DOI: 10.1055/s-0037-1618981
Thrombose und Onkologie: Übersichtsarbeit
Schattauer GmbH

Diagnostik und Therapie Tumorassoziierter venöser Thromboembolien – was sagen die Leitlinien?

Diagnosis and therapy in cancer-associated thromboembolism – what about guideline recommendations?
A. Matzdorff
1   Asklepios Klinik Uckermark, Innere Medizin II, Schwedt
› Author Affiliations
Further Information

Publication History

Publication Date:
10 January 2018 (online)

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Zusammenfassung

Tumorwachstum und Gerinnungsaktivierung sind pathophysiologisch eng miteinander verknüpft. Deshalb sind Tumor-assoziierte venöse Thromboembolien (VTE) häufig. Während stationär aufgenommene Tumorpatienten eine Thromboseprophylaxe erhalten wird dies für ambulante Patienten in der Regel nicht empfohlen. Wenn Tumorpatienten doch eine VTE entwickeln, dann sollten sie mit einem NMH in therapeutischer Dosis für 3–6 Monate behandelt werden. Vitamin-KAntagonisten haben ein höheres Blutungsrisiko und für NOAKs gibt es noch keine ausreichenden Daten. Nicht nur Hämato-Onkologen, sondern alle Ärzte, die Tumorpatienten betreuen, sollten mit den aktuellen Leitlinienempfehlungen vertraut sein. Auch die Patienten sollten über die Symptome einer VTE informiert sein.

Summary

Oncogenic transformation is closely linked to coagulation activation and cancer-associated venous thromboembolism (VTE) is a common problem. Guidelines recommend thromboprophylaxis with a low molecular weight heparin for hospitalized cancer patients. However, thromboprophylaxis is not customarily advised for ambulatory cancer patients. Cancer patients with VTE are usually treated with a low molecular weight heparin for 3–6 months. Vitamin K antagonists have a higher bleeding risk and there are not sufficient data to recommend any of the new oral anticoagulants. All physicians taking care of cancer patients should be aware of the current guideline recommendations. Oncology professionals should educate patients about the signs of VTE.

English version available at: http://www.phlebologieonline.de

Schlüsselwörter

Krebs - venöse Thromboembolie - Leitlinien - Tumor - Prophylaxe

Keywords

Cancer - venous thromboembolism - guidelines - tumour - prophylaxis
 

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